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650-575 LCSAS Cisco Lifecycle Services Advanced Security

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650-575 exam Dumps Source : LCSAS Cisco Lifecycle Services Advanced Security

Test Code : 650-575
Test designation : LCSAS Cisco Lifecycle Services Advanced Security
Vendor designation : Cisco
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LCSAS Cisco Lifecycle Services

How 3M and Cisco utilize "expertise systems" to inspire Innovation | killexams.com real Questions and Pass4sure dumps

As an advisor and consultant to some of the world's biggest and most creative corporations, during the eventual few years I've seen a stagy shift within the C-Suite.

today's executives recognize the urgency to ascertain and set aside money into disruptive technology. whether it's blockchain, self reliant cars or the web of things, the frenzy makes feel. Strategic innovators scan with expertise. Investing time and money in something unproven is cost the chance. if you don't disrupt, they say, you'll finally live disrupted.

I've had the privilege to execute a miniature work with two massive businesses universal for his or her long-term center of attention and investments in innovation - 3M and Cisco. like many organizations, they result disruptive applied sciences to construct their future products and functions.  however 3M and Cisco also utilize a similar approach to their know-how-inspired innovation to effect it a sustainable and repeatable technique. here's how the they execute it:

explore the Disrupters, however execute not stop There

3M recently established an initiative on "linked Roads" to tap into the approaching disruption from self sufficient vehicles.  3M's scientists are developing modern materials for street signals so sensors on automatic motors can music signals as they velocity by way of, practically enabling both people and machines to navigate roadways together in a authentic way by "studying" the identical indications.

Cisco applied the verve of the information superhighway of issues through the utilize of data from lots of related instruments to create what it calls "intent-based mostly networking" - aggregating great amounts of records promises to ultimately array a modern smooth of synthetic intelligence.

no matter if these experiments develop into the subsequent sizable component for 3M and Cisco is any person's wager. that's because the biggest challenge with step forward innovation is that the market success of any given product or carrier according to modern expertise is totally unpredictable.

for most businesses, the query is never even if to scan, but a bit a way to continually create modern profits streams over time. long-term innovators like 3M and Cisco appreciate that in today's world enamored by way of the allure of disruptive expertise, it live essential to investigate the expertise online game changers, whereas no longer become blinded by way of them. bound, a great innovation might also near from a modern to the realm know-how, but leveraging existing technical capabilities is equally essential, if no longer a unbiased greater predictable driver of sustainable enterprise increase.

Use expertise systems to pressure lengthy-term boom

notwithstanding they're in fully different industries, 3M and Cisco both utilize "expertise platforms" to e-book their innovation efforts. These groups admire they want a mode to inspirit innovation that enormously improves upon state-of-the-art offerings or creates totally modern market opportunities - although these innovations aren't always "disruptive" per se.

A "platform" is a technology that will also live used as the basis for growing various items or services.  one among 3M's most renowned know-how systems is "adhesives," which has allowed the company to create products like submit-It Notes, super Sticky Easel Pads, Scotch tape, stretch free up Command strips, efficiency adhesives to exchange rivets on airplanes, scientific tape, and the listing goes on.

The issue in most groups is that leadership either only goes for the great bets or gets caught in a single-minded focal point on the miniature stuff. If they simplest vibrate for the fences, we'll omit the casual to rating on singles, doubles, or triples as smartly. technology platforms supply a means to ranking on quite a lot of forms of improvements that advocate win the lengthy online game.

outline Your structures

Most companies respect the theory of "core knowledge" - the combination of abilities, supplies, and strengths that aid differentiate an organization in the marketplace. while technology might contribute to a company's ordinary core advantage, expertise systems are a a lot more selected option to win into account and win erudition of know-how to power innovation.

3M, as an instance, makes utilize of a "periodic table" structure to classify 46 technology platforms into four areas that focal point its innovation efforts: substances, tactics, capabilities, and purposes. in accordance with Gayle Schueller, 3M's vp of recent structures, "3M's expertise systems advocate sheperd efforts to withhold world-category capabilities and differentiated capabilities that develop selected products, services, methods, and enterprise fashions."

Cisco applies a special strategy to defining its platforms, though the influence is similar. Cisco's features business structures some of its innovation platforms in keeping with what's necessary to carry services for open supply software. The idea is basic. based on Stan Baginskis, Cisco services Sr. Director of expertise strategy and boom, "Accelerated adoption of open supply utility creates a casual to supply functions to aid their consumers utilize the application to its plenary talents."

To the layperson, open source application may live almost unparalleled (like FD.io, OpenDaylight, and so forth.), however many of these equipment gain eddy into the technical backbones that serve run the networks, safety, storage, and cloud capabilities of many great corporations. because the application is open supply, the software itself is free, however businesses are left to their own contraptions to enforce it.

Cisco makes utilize of a simple framework to portray its structures, each of which is a step in the life cycle of how agencies select, customize, enforce, and advocate their utility tools. as an instance, Cisco views its platforms as Advisory, Implementation, development, Technical aid, answer Validation, and Optimization. each and every of those structures comprise quite a lot of provider offerings that serve clients profit from their utility.

Make platforms Strategic

no longer every technology is a platform for every enterprise.  Some applied sciences can live valuable for constructing specific items, but they may also not live the groundwork for future aggressive expertise via innovation. 3M, as an example, makes utilize of paper in items like set aside up-It notes and easel pads. but 3M sources paper from many suppliers, so the company doesn't view it as a core expertise platform. Any business can purchase bulk paper to effect utilize of in their products, which is why it live now not commonly seen as a differentiator when it involves innovation. due to this fact, 3M makes a speciality of platforms it could wield and result to modern products in methods that almost any rivals can not.

in a similar fashion, Cisco is rarely making an attempt to write down code to further every open supply software device. quite, Cisco looks at the particular software where valued clientele gain the greatest necessity and Cisco has the most expertise to offer. as an instance, of the dozens of open supply utility tools accessible, some are greater susceptible to security breaches than others. Cisco focuses on constructing out its safety consulting features specially geared to consumers the usage of the utility that may most profit from extra protection aid, pretty much defining its platform (e.g., protection implementation) on the theme of a given open supply tool.

expertise systems serve as the groundwork for product and service innovation, and the best structures aid create market differentiation.

strengthen platforms with clients

know-how is barely technology except it solves a consumer issue. In trendy world focused on design pondering, the customer experience, and customer centricity, it may well reflect counter-intuitive to center of attention on know-how-driven innovation. but the foremost know-how systems naturally silhouette the consumer advantages or problems that they could advocate handle, so that they're related to what basically adds value to the market.

Cisco, as an example, started working with an colossal US wireless communications tremendous to serve the business optimize an open source records analytics appliance referred to as PNDA (pronounced "Panda"). a lot of records passes during the carrier issuer's community every day in the configuration of calls, texts, movies, augmented and digital fact games, and other cell web site visitors.  PNDA helps businesses collect, seize, and dissect this facts whereas growing visual stories for what's occurring across the network. whereas the PNDA open supply utility is tremendous for knowing what's presently occurring, by using itself it doesn't deliver prescriptive actions to win - which is necessary when you are attempting to ensure that the community would not Get "clogged up" and decelerate for conclusion-person valued clientele. With this perception and working alongside their client, Cisco built rules around what to execute with PNDA's reports to prevent network outages and preserve issues working smoothly, before complications win place. The approach helped Cisco find a market want while concurrently validating the cost of extra investments into its PNDA "implementation" and "building" services systems.

combine platforms to Innovate

individual know-how platforms are the springboard for innovating modern products and services. it really is how 3M used adhesives to effect Command strips.

New market alternatives frequently near from combining systems. 3M's periodical table of know-how systems allows for its engineers to fuse and match applied sciences to with ease explore modern probabilities and quickly create modern products. 3M's elevated efficiency Window films, as an example, are a blend of 4 systems: Adhesives, films, Nano-expertise, and light administration. with the aid of combining these applied sciences, 3M has tapped into a lot of modern markets like window tinting for vehicles, power management for business constructions through tinted glass, and security glass for home windows to avoid shattering from spoil-ins and earthquakes.

Cisco carried out an identical synergies when it utilized its "building" and "implementation" structures in its work on PNDA. via combining these two systems perquisite into a sole elevated cost answer for telecommunication service providers, Cisco now has an providing for other purchasers that will also live scaled across the market. 

retain It simple

while the word "platform" is as buzzwordy as "disruption" these days, any business can faucet into the verve of technology platform innovation via retaining issues essential. define what makes your offerings in fact wonderful, classify these capabilities in anything way makes probably the most experience, after which flip people lax to explore, combine, and create solutions with purchasers that resolve actual complications.

that's how to create a way of life of innovation. and that's the way to develop into a protracted-time period innovator.

published on: Jun 19, 2018


Cisco releases modern developer functionalities throughout intent-primarily based networking platform | killexams.com real Questions and Pass4sure dumps

Cisco is releasing modern developer equipment across its intent-based mostly networking platform and open APIs into Cisco DNA core, the command and control centre for campus, offshoot and belt intent-primarily based networks. DNA middle turns the community from a blend of hardware contraptions perquisite into a sole gadget. With the supply of network-broad APIs, Cisco said it now enables builders to without problems programme this gadget, tapping into any the analytics and perception the community can give. Cisco is also asserting that its developer neighborhood, DevNet, surpassed 500,000 individuals. Cisco is also asserting three modern developer initiatives to gas its innovation ecosystem, DevNet Ecosystem change, DevNet DNA Developer middle and DevNet Code trade. 

Already, 15 Cisco companions gain constructed resourceful items on the DNA core platform and are demonstrating them at Cisco are living.

In edifice its giant and energetic DevNet community, Cisco mentioned it launched a brand modern source of innovation as the network turns into increasingly programmable.

The DevNet Ecosystem change developer initiative makes it handy to ascertain and partake an software or platform developed for Cisco systems. DevNet Code alternate offers builders a status to entry and partake utility to rapidly build next-technology purposes and workflow integrations. DevNet DNA Developer middle is a one-stop-store for developers to build functions and integrations on the DNA core platform. It provides finished substances, capabilities, utilize situations and gaining erudition of materials for developers.

the modern DNA core capabilities are scheduled to live purchasable during the summer. purchasers should buy these modern functionalities from Cisco and its companions by way of existing subscription presents. DevNet's Ecosystem exchange, Code alternate, and DNA Developer middle are available now. Cisco and its companions offer a plenary lifecycle of features to aid customers streamline the journey to definitely intent-primarily based networks.


LaSalle solutions ‘riding Evolution’ at Cisco live 2018 | killexams.com real Questions and Pass4sure dumps

news and research before you hear about it on CNBC and others. title your 2-week free affliction to StreetInsider premium here.

ROSEMONT, sick., June eleven, 2018 (GLOBE NEWSWIRE) -- LaSalle solutions, a leading provider of technology lifecycle management features, is exhibiting today in sales space 1851 at Cisco are living, Cisco’s annual IT and communications convention, taking location June 10–14 on the Orange County convention core in Orlando. LaSalle will live in the world of solutions any the way through the week to expose the superior facets of LAMPSM, the company’s industry-leading cloud-based asset and preservation contract administration platform.

Cisco live offers a divorce combination of in-depth technical education, working towards and chopping-aspect perception from the experts and businesses which are surroundings the agenda for the future of know-how and company.

“Cisco reside is a very compliant possibility for us to unite with the partners and shoppers they work with each day, in addition to to create modern relationships,” referred to Steven Robb, president of the solutions neighborhood at LaSalle solutions. “we are involved for showing company to sales space 1851 how their group of consultants and business-leading LAMP platform are changing the style their clients control the lifecycle of their Cisco hardware and application.”

As a leading provider of expertise lifecycle solutions and considered one of an elite neighborhood of Cisco partners with both Gold and Lifecycle sheperd fame, LaSalle solutions gives you finished options that complement Cisco capabilities via asset discovery, administration and upkeep contract accuracy and optimization using LAMP.

LAMP demos can live given during the week within the LaSalle sales space, where guests will also gain an occasion to win a photo with the LaSalle-sponsored NASCAR race car parked in the middle of the business’s exhibition area.

LaSalle’s group of Cisco licensed Internetwork experts (CCIEs) are additionally at Cisco reside this week to host informational sessions in the Cisco rendezvous center, room 21. periods win belt these days, Monday, June 11, via Thursday, June 14, from 12:30 to 1:30 p.m. Session topics encompass the information superhighway of things (IoT), utility-described vast belt community (SD-WAN), digital network architecture (DNA), gadget automation, and more.

“The technology business is consistently altering, and we're working challenging to no longer simplest accommodate to these adjustments, but also live confident that their customers are doing the identical,” referred to Robb. “The legacy of LaSalle options is one of nonstop evolution. They hearken to their purchasers and work closely with their partners to develop with them as wants and know-how alternate. collectively, we're using evolution to reside miles forward of the curve.”

About LaSalle solutions

centered in 1980, LaSalle solutions is a number one provider of expertise lifecycle asset management capabilities. LaSalle permits its shoppers to enrich their expertise operations through more suitable processes, management and reporting for greater planning and recur on funding. LaSalle solutions’ strategies, extraordinary customer service and strong, market-leading cloud-primarily based toolset, LAMP, permit purchasers to acquire improved enterprise results via transparency and professional results at their fingertips.

LaSalle options is a division of MB equipment Finance LLC, a subsidiary of MB financial financial institution, N.A., a business bank headquartered in Chicago. MB monetary Inc. is the publicly traded protecting business for MB fiscal financial institution, N.A. and is traded on the NASDAQ as “MBFI.”

For more guidance on LaSalle options, gladden visit www.lasallesolutions.com and www.YouTube.com/LaSalleSolutions.

LaSalle options and LAMP are registered trademarks of LaSalle options within the u.s..

a photo accompanying this announcement is obtainable at http://www.globenewswire.com/NewsRoom/AttachmentNg/1d9682bc-1fc6-4c29-bb4d-a28b826faed3

Press Contact Beth Kirshenberg LaSalle answers847.823.9600 advertising@elasalle.com

Primary Logo

supply: LaSalle solutions

650-575 LCSAS Cisco Lifecycle Services Advanced Security

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650-575 exam Dumps Source : LCSAS Cisco Lifecycle Services Advanced Security

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FDA recollects Axcil and Desirin | killexams.com real questions and Pass4sure dumps

The U.S. meals and Drug Administration announced the respect of two sexual enhancement items -- Axcil and Desirin -- because of undeclared, ingredients.

Axcil -- described as a "male enhancement" product -- and Desirin -- talked about to "promote feminine sexual characteristic" -- are over-the-counter medication allotted nationwide by using TWC world LLC of Mountain View Calif. The company initiated the intentional win into account after FDA assessments found the products comprehend sildenafil, the lively ingredient of a FDA-authorised drug to deal with erectile dysfunction, in addition to two analogs -- sulfosildenafil and sulfohomosildenafil.

The FDA mentioned the undeclared chemical compounds pose a threat to consumers as a result of they could gain interaction with nitrates present in some prescription medication.

each Axcil and Desirin are sold via the cyber web in a 15-pill blister pack packaged in a box.

patrons with questions can contact the business at 650-575-0828.

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OncoMed presents information on dissimilar Anti-cancer flow cellphone programs at American affiliation for melanoma research Annual assembly | killexams.com real questions and Pass4sure dumps

OncoMed prescription drugs, Inc. (Nasdaq: OMED), a scientific-stage company developing novel therapeutics that target melanoma flow cells (CSCs), or tumor-initiating cells, these days introduced data from an oral presentation and eight poster shows at the American affiliation of cancer analysis (AACR) Annual meeting in San Diego, CA April 5-9, 2014. The analysis presented at AACR spotlight OncoMed's drug discovery platforms along with preclinical and biomarker discoveries on its scientific-stage product candidates and a number of rising product candidates. a brief abstract of each and every presentation is provided beneath.

"The 9 shows at this yr's AACR Annual meeting expose the breadth and depth of OncoMed's preclinical research and discovery work. Encompassing a lot of their clinical- and preclinical- stage candidates, facts being presented this week highlight the mighty anti-cancer flow cell undertaking considered throughout their portfolio, the alternatives to fuse their compounds with commonplace-of-care, and their ongoing biomarker identification efforts being applied to programs in clinical development," observed John Lewicki, PhD, executive vp, Chief Scientific Officer.

Oral Presentation

Timothy Hoey, PhD, OncoMed's Senior vp of cancer Biology, gave an oral presentation entitled "using PDX models for anticancer drug screening" as a fraction of a methods Workshop on functions of affected person Derived Xenograft fashions to Translational cancer analysis. Dr. Hoey discussed the principal role of OncoMed's affected person-derived tumor financial institution to respect anti-tumor and anti-cancer flow cellphone endeavor of its novel drug candidates; supply insights into skills scientific indications and dosing regimens; and generate and respect predictive biomarker hypotheses for software in medical trials. OncoMed has developed a sizable financial institution of affected person-derived tumors, comprising greater than 200 tumors from a variety of tumor types, including the targeted phenotypic, useful and genomic characterization of each and every tumor.

Poster shows

medical-stage classes

Belinda Cancilla, PhD, Director, introduced abstract #910, "NOTCH3 expression is predictive of efficacy in pancreas tumor models handled with OMP-59R5, a monoclonal antibody focused on the NOTCH2 and NOTCH3 receptors," within the Predictive Biomarker 1 Poster Session. Expression of NOTCH3 mRNA by using subsequent-era sequencing in pancreatic tumor fashions correlated with response to OncoMed's anti-Notch2/three antibody, OMP-59R5, the status tumor efficacy correlated with NOTCH3 biomarker levels. A analysis utilize simplest (RUO) qPCR assay for quantifying NOTCH3 mRNA expression the usage of Formalin-fixed, Paraffin-Embedded (FFPE) samples and an immunohistochemistry (IHC) assay for measuring tiers of NOTCH3 protein in tumor samples gain been developed. These assays could live used to correlate NOTCH3 ranges with patient response in ALPINE, a side 1b/2 clinical affliction of OMP-59R5 in first-line superior pancreatic cancer sufferers. OMP-59R5 is fraction of OncoMed's collaboration with GlaxoSmithKline (GSK).

Marcus Fischer, associate Scientist, offered summary #3048, "OMP-59R5 (Anti-Notch2/three) inhibits tumor boom and reduces cancer flow phone frequency in patient derived SCLC xenografts," within the cancer flow cell Phenotype and performance 2 Poster Session. OMP-59R5 became enormously constructive in decreasing tumor boom and melanoma flow phone populations in fashions of miniature cellphone lung cancer (SCLC). treatment with OMP-59R5 elevated the expression of differentiation markers and decreased CSC and Notch pathway genes. OncoMed is at present evaluating OMP-59R5 within the side 1b/2 PINNACLE affliction in patients with SCLC.

Dr. Hoey also offered summary #1898, "The blend of gemcitabine/nab-paclitaxel and anti-DLL4 (demcizumab) produces synergistic boom inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic melanoma," as fraction of the modern Diagnostics, Therapeutic concentrated on, and Response Assessments Poster Session. Demcizumab, in blend with nab-paclitaxel (Abraxane®) and gemcitabine produced profound anti-tumor pastime and anti-CSC activity in a collection of pancreatic tumor xenografts. The triple blend of demcizumab, Abraxane and gemcitabine turned into greater efficacious compared with the combination of demcizumab plus gemcitabine lonesome and in several instances ended in shrinkage of tumors to undetectable stages. OncoMed is at present trying out the aggregate of demcizumab with Abraxane/gemcitabine in a fraction 1b behold at of superior pancreatic cancer sufferers and plans to initiate a section 2 study during this patient inhabitants later this yr. The demcizumab program is a fraction of OncoMed's collaboration with Celgene.

Story Continues

Chun Zhang, Senior Scientist II, offered summary #2830, "Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) with the aid of mining gene expression information of human breast melanoma xenografts," within the Predictive Biomarkers 2 Poster Session. A novel six-gene signature changed into derived based on the responsiveness of breast cancer xenografts to vantictumab and has been used successfully to precisely predict the responsiveness of six extra xenograft models to this antibody. A scientific utilize behold at various for this six-gene signature is under edifice and should live used in the analysis of sufferers from OncoMed's ongoing side 1b study of vantictumab in breast melanoma. Vantictumab is a component of OncoMed's Wnt pathway collaboration with Bayer Pharma AG (Bayer).

Pete Yeung, associate Scientist, introduced summary #1907, "Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor expand and reduces tumor-initiating mobilephone frequency in patient-derived hepatocellular carcinoma and ovarian melanoma xenograft models," in the melanoma flow cell Phenotype and role 1 poster session. Researchers at OncoMed evaluated OMP-54F28 in models of hepatocellular cancer (HCC) and ovarian melanoma, two of the three signs that are at the moment being pursued in fraction 1b studies of this therapeutic candidate. OMP-54F28 proven undertaking as a single-agent and in combination with sorafenib in 4 HCC fashions and exhibited sole agent and blend pastime with paclitaxel in two ovarian cancer xenografts. A marked reduction in CSC frequency became accompanied following remedy with OMP-54F28 by myself and in blend with chemotherapy in both tumor varieties. OMP-54F28 additionally caused the differentiation of those tumors and blocked Wnt pathway genes. OMP-54F28 is a component of OncoMed's collaboration with Bayer.

Wan-Ching Yen, PhD, Senior Scientist II introduced summary #4547, "enhanced anti-tumor outcome of WNT pathway antagonists in blend with taxanes," within the mobile Cycle Mechanisms of Anticancer Drug motion Poster Session. The aggregate of Wnt pathway antagonists with taxanes in affected person-derived pancreatic or ovarian xenografts confirmed additivity and/or synergy that exceeded that observed when Wnt blockade is combined with DNA synthesis inhibitors gemcitabine and carboplatin. both Wnt pathway antagonists and taxanes are lively on the G2/M side of the telephone cycle, which is notion to account for accompanied synergies. Taxanes are presently being mixed with either vantictumab or OMP-54F28 in divorce ongoing side 1b stories.

"The presentations at AACR via OncoMed's scientists fortify the clinical data being generated across their evolution classes," pointed out Jakob Dupont, OncoMed's Chief scientific Officer. "These analysis outcomes give efficient insights on capabilities combination regimens, where the addition of ordinary-of-care treatment plans may finest enhance the exercise of their anti-melanoma flow cell candidates and ebook their predictive biomarker programs."

rising Preclinical programs

Dr. Yen additionally introduced abstract #207, "twin focused on of DLL4 and VEGF signaling by using a novel bispecific antibody inhibits tumor growth and reduces cancer flow cellphone frequency," in the flow cell enlargement and melanoma flow mobilephone concentrated on Poster Session. OMP-305B83, OncoMed's novel elevated affinity bispecific antibody focused on DLL4 and VEGF established great in vivo anti-tumor efficacy in a number strong tumor xenografts, delayed tumor recurrence following termination of chemotherapy, and decreased the frequency of cancer flow cells. twin inhibition of these two targets seems to demonstrate additive anti-tumor undertaking at doses the status blockade of both goal on my own elicited sub-most desirable endeavor. OncoMed expects to file an Investigational modern Drug (IND) utility with the us meals and Drug Administration for OMP-305B83 within the second half of 2014.

Austin Gurney, PhD, Senior vice chairman of Molecular and cellular Biology at OncoMed, presented summary #1764, "Inhibition of R-spondin (RSPO) signaling reduces the growth of distinctive human tumors," within the modern goals and agents 1 Poster Session. Inhibition of RSPO-LGR signaling with novel anti-RSPO antibodies inhibited tumor expand in numerous affected person derived xenograft models, including ovarian, colon, non-small mobile lung and pancreatic cancers. The RSPO blockade turned into constructive in decreasing tumor growth in tumors overexpressing RSPO, including tumors with genetic translocations, suggesting that levels of RSPO expression can also role biomarkers in settling on patients surely to reply to RSPO blockade. OncoMed expects to file an IND for its lead anti-RSPO3 antibody in late 2014 or early 2015.

each the anti-DLL4/anti-VEGF antibodies and anti-RSPO programs are encompassed inside OncoMed's collaboration with Celgene.

"Our robust presence at this 12 months's AACR Annual assembly reflects the productivity of OncoMed's platform applied sciences and their commitment to continued discovery analysis, proprietary human tumor xenograft models, and predictive biomarkers," renowned Paul J. Hastings, Chairman and Chief government Officer. "OncoMed's preclinical and translational drugs work informs and supports the efforts of their edifice company, which is presently conducting 15 medical trials for 5 anti cancer flow cellphone brokers, and fuels the boom of their pipeline of anti-cancer flow cell therapeutics, as exemplified via the presentations of in vivo tumor efficacy facts for their pre-IND candidates, OMP-305B83 and Anti-RSPO3."

About melanoma flow Cells

cancer flow cells, or CSCs, are the subpopulation of cells in a tumor answerable for driving growth and metastasis of the tumor. CSCs, also known as tumor-initiating cells, array confident properties which encompass the talent to divide and give ascend to modern CSCs by the utilize of a process known as self-renewal and the talent to differentiate or change into the other cells that configuration the bulk of the tumor. common cancer medication target bulk tumor cells however gain confined gain an impact on on CSCs, thereby offering a path for recurrence of the tumor. OncoMed's product candidates target CSCs by using blocking off self-renewal and riding differentiation of CSCs towards a non-tumorigenic state, and additionally gain an outcome on bulk tumor cells. OncoMed believes its product candidates are distinctive from the existing generations of chemotherapies and focused treatment plans, and gain the competencies to greatly influence melanoma medicine and the clinical outcomes of sufferers with cancer.

About OncoMed pharmaceuticals

OncoMed prescribed drugs is a clinical-stage company concentrated on discovering and establishing novel therapeutics targeting cancer flow cells. OncoMed has 5 anti-cancer product candidates in clinical development, including demcizumab (Anti-DLL4, OMP-21M18), OMP-59R5 (Anti-Notch2/3), OMP-52M51 (Anti-Notch1), vantictumab (Anti-Fzd7, OMP-18R5), and OMP-54F28 (Fzd8-Fc), which target key cancer flow phone signaling pathways including Notch and Wnt. OncoMed has two different antibodies in preclinical building, OMP-305B83 (Anti-DLL4/Anti-VEGF bispecific) and Anti-RSPO3, with Investigational modern Drug filings deliberate for late 2014 or early 2015. OncoMed is additionally pursuing discovery of additional novel anti-CSC product candidates. OncoMed has fashioned strategic alliances with Celgene company, Bayer Pharma AG and GlaxoSmithKline (GSK). additional information will also live discovered on the company's site: www.oncomed.com.

ahead-looking Statements

To the extent that statements contained in this press release are not descriptions of historical information involving OncoMed prescribed drugs, they're forward-looking statements reflecting the existing beliefs and expectations of management made pursuant to the secure harbor provisions of the deepest Securities Litigation Reform Act of 1995, including OncoMed's expectations concerning the capacity of OncoMed to strengthen its research and edifice pipeline, including its discovery and preclinical pipeline and its anti-CSC therapeutics in clinical trials; OncoMed's potential to find and expand novel anti-CSC therapeutics; the tolerability of OncoMed's product candidates at efficacious doses; the skills of OncoMed's product candidates to greatly affect cancer medication and the medical result of sufferers with melanoma; the capabilities for a hit construction of predictive biomarkers for OncoMed's product candidates; the timing of scientific trials for OncoMed's product candidates; and the timing of Investigational modern Drug filings for OncoMed's product candidates, together with OMP-305B83 and Anti-RSPO3. Such ahead-looking statements hold vast hazards and uncertainties that may trigger OncoMed's medical edifice courses, future consequences, performance or achievements to vary significantly from those expressed or implied by using the forward-looking statements. Such risks and uncertainties encompass, amongst others, the uncertainties inherent within the preclinical and scientific evolution process; the hazards and uncertainties of the regulatory approval method; OncoMed's dependence on its collaboration companions, including Celgene, GSK and Bayer, for the funding of its partnered classes; OncoMed's talent to hoist additional capital to serve the evolution of its unpartnered programs; OncoMed's dependence on the edifice and advertising efforts of its partners for the business success of its partnered product candidates; OncoMed's reliance on third events to habits confident preclinical reviews and any of its scientific trials; OncoMed's reliance on sole supply third-celebration contract manufacturing organizations to manufacture and provide its product candidates; OncoMed's capability to validate, develop and procure regulatory popularity of accomplice diagnostics; OncoMed's capacity to obtain market acceptance and business success of its product candidates as soon as regulatory approval is done; OncoMed's talent to find, better and commercialize extra product candidates; the capability of rivals to find, further or commercialize competing products greater promptly or extra effectively; OncoMed's dependence on its Chairman and Chief government Officer, its Chief Scientific Officer, its Chief clinical Officer and different key executives; casual of third birthday party claims alleging infringement of patents and proprietary rights or in search of to invalidate OncoMed's patents or proprietary rights; and the skill of OncoMed's proprietary rights to offer protection to its applied sciences and product candidates. OncoMed undertakes no duty to update or revise any forward-looking statements. For a further description of the hazards and uncertainties that could occasions specific results to disagree from these expressed in these ahead-searching statements, in addition to risks concerning OncoMed's business in common, behold OncoMed's Annual file on benign 10-okay for the fiscal yr ended December 31, 2013, filed with the Securities and change fee on March 18, 2014.

CONTACT: Investor Contact: OncoMed prescribed drugs Shari Annes Investor family members (650) 888-0902 shari.annes@oncomed.com

Media Inquiries: BCC partners Karen L. Bergman or Michelle Corral (650) 575-1509 or (415) 794-8662 kbergman@bccpartners.com or mcorral@bccpartners.com OncoMed pharmaceuticals, Inc. brand

supply: OncoMed pharmaceuticals, Inc.

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© 2014 Benzinga.com. Benzinga doesn't supply funding counsel. any rights reserved.


Farmers halt auction at Satana APMC | killexams.com real questions and Pass4sure dumps

NASHIK: Farmers on Tuesday halted public sale at the Satana Agriculture defer Market Committee (APMC) wholesale onion market for an hour and staged a street blockade in protest in opposition t low fees to the commodity in the morning session.The auction resumed an hour after the APMC officials satisfied the agitating farmers. At different APMCs within the district, the public sale of onion persisted as tolerable with yardstick wholesale expenditures being recorded in the latitude of Rs seven-hundred to Rs 1,a hundred a quintal.

Satana APMC secretary A k Bhamare mentioned, "The farmers halted onion auction for an hour from 10.30 in the morning to protest the low prices. They additionally staged a 'rasta roko' backyard the main gate of the APMC. The public sale, despite the fact, resumed at 11.30 am after they satisfied them to participate in the process. The habitual wholesale onion cost turned into Rs 850 a quintal, whereas the minimal and highest expenses were recorded at Rs one hundred and Rs 1,300 a quintal, respectively. respectable nice onions obtained costs in the ambit of Rs seven hundred to 1,300 a quintal, whereas the terrible first-class ones bought fees as much as Rs 600 a quintal."

He spoke of, "The hailstorms and unseasonal rains in February and March had hit Satana tehsil, affecting the high-quality of onions. most of the crops achieving the market are of sinful exceptional. due to this fact, there's massive a inequity in the wholesale onion expenses. The compliant fine onions are getting respectable prices, while the poverty-stricken first-class plants gain become reduce costs."

Shetkari Sanghatana (Nashik district) president Govind Pagar spoke of, "How will the farmers live on in the event that they cannot even Get well their production prices? they are able to stage demonstrations across talukas within the district if there isn't any improvement in onion costs inside a week."

An legitimate at Lasalgaon APMC observed, "the advent of onions within the ambit 15,000 to 18,000 quintals a day, but the excellent of onions is not so decent as most of the crop has been broken within the concurrent hailstorms and unseasonal rains. best 40 per cent of the entire arrival is of decent great."

The common wholesale onion expense at Lasalgaon changed into recorded at Rs 950 a quintal on Tuesday. The minimum and highest fees had been recorded at Rs 300 and Rs 1,478 a quintal, respectively. around 18,000 quintals of onions gain been auctioned at Lasalgaon throughout the day.

At Pimpalgaon APMC, the commonplace wholesale onion expense changed into recorded at Rs 1,100 a quintal. The minimal and optimum expenditures gain been recorded at Rs 351 and Rs 1,770 a quintal, respectively. round 14,000 quintals of onions were auctioned at Pimpalgaon.

The common wholesale onion fee at the Yeola APMC become recorded at Rs 700 a quintal. The minimal and optimum fees had been recorded at Rs 200 and Rs 1,000 a quintal, respectively. around 1,500 quintals of onions gain been auctioned at Yela.

At Satana APMC, the habitual wholesale onion cost became recorded at Rs 850 a quintal. The minimal and highest prices gain been recorded at Rs a hundred and Rs 1,000 a quintal, respectively. around four,500 quintals of onions gain been auctioned at Satana.

normal wholesale onion fees in Nashik APMCs

APMCs Nov 29 Dec 6 Jan 13 Feb 5 April 10 April 17 April 25 can also 6

Lasalgaon 1,700 1,750 925 740 725 1,011 975 950 Pimpalgaon 1,651 1,seven-hundred 950 675 801 921 800 1,a hundred Yeola 1,300 1,600 850 650 575 750 740 700 *observe: any figures are in rupee per quintal


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