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Cisco Consolidates Collaboration beneath Webex | existent questions with brain dumps

April 18, 2018

Cisco has converged its team collaboration solution (previously known as Cisco Spark) and Webex conferences solution. And it’s moved the Cisco Spark options below the Webex company.

So Cisco Spark is now called Webex teams. Cisco Spark aide is now Webex Assistant. And the Cisco Spark Board from this present day forward shall exist conventional as the Webex Board.

“everybody knows the Webex company. It’s like Kleenex,” Jonathan Rosenberg, Cisco VP and CTO collaboration, observed throughout a press briefing these days.

all the passage through his keynote presentation this morning on the Cisco Collaboration Summit, Rosenberg spoke of how the industry has simplified Webex teams for ease of use. the brand modern colour palette is light on the eyes, he spoke of. people can exercise a separate button to create a modern collaboration belt and execute a number of other things. clients can associate meetings through their calendars if they so choose. And APIs enable Webex points to are animated within existing industry functions and workflows.

“It’s minimal. It’s graceful. It’s visually amazing,” he said. “We’ve taken everything out apart from everything that’s necessary.”

Rosenberg delivered: “here is now a full-fledged meeting utility. I don’t absorb to depart in different places.”

At nowadays’s undergo in Phoenix, Cisco additionally:

• unveiled a hardware device referred to as Webex Share,

• published augmented verisimilitude performance it created with the Apple SDK is now attainable on iOS gadgets, and

• introduced modern elements to its Flex mode that build it less complicated for Cisco clients to buy its collaboration solutions.

Webex participate allows businesses to seriously change common TVs into Webex communications and collaboration interfaces. Pricing has not yet been introduced for this hardware machine, which may exist obtainable later this 12 months.

Cisco confirmed a modern augmented verisimilitude function of Webex that’s obtainable on Apple instruments working iOS. The enterprise confirmed how a revenue or advertising person may disclose a 3-dimensional photo of a product, and even rotate the product, to demo its own wares to clients.

And Flex mode now comprises an entire assembly suite with bundled audio, bundled storage, and the means to assist up to 1,000 individuals in a meeting.

Rowan Trollope, senior vp and commonplace supervisor of the purposes group, additionally referred to Cisco’s pastime is taking synthetic intelligence beyond command and control. The next step in the AI journey includes herbal language figuring out, he observed, adding that’s a passionate belt of analysis at the moment.

Tom Puorro, vice president and widespread supervisor of Cisco’s UC expertise group, then took the stage to provide a “sneak preview” demo of how AI might enable a knowledge employee to conclusion a title through adage anything like “agenda next meeting in two weeks,” and AI may issue at the schedules of everybody on the current name, determine a time two weeks out that works for each person, after which immediately forward a meeting invite to each person in that neighborhood. Puorro observed Cisco intends to interject whatever alongside these traces sooner or later, but didn’t deliver a timeline for that.

Edited through Maurice Nagle

A Day within the lifetime of a modern applications Developer – DevOps collection, participate three | existent questions with brain dumps

Welcome back! if you followed my previous posts you're actually fluent on Docker and Kubernetes, so now let’s reserve that expertise into observe!

The life of a DevOps crew

have you ever heard about DevOps from distinctive sources and still don’t absorb a lucid conviction what it in reality is? Would you like to create a relationship with modern Line-of-enterprise owners, however reckon you can't talk their DevOps slang?  comprehend me and they can explore the lifetime of a DevOps crew, so that you can reckon their particular concerns and challenges.

You could already exist established with different environments, like networking, however DevOps is a unique world, with necessities for achievement (both technical and social) commonly requiring the crew to speculate in a completely different means.

on the equal time DevOps approach can besides exist utilized to networking challenges, so it is captious to abide in intellect these foundational DevOps ideas very neatly earlier than going into those pleasing and inventive options.

during this progression of posts and learning labs they are able to cowl what DevOps is, from a really purposeful point of view. It is too frequently that you attend a DevOps session and are available out with nothing however fluffy ideas about it. That stops today. In privilege here weeks they can cowl everything foundational capabilities on DevOps, and reserve it to follow in distinctive palms-on environments. I covenant this may exist a thrilling depart back and forth!

construction and Operations crew Challenges

Let’s birth by means of exploring one of the vital challenges structure and Operations teams have:

  • All utility should rush on a platform, so that it will probably give a provider. And software lifecycle, from its inception to the second it runs on a construction ambiance, comprises a number of steps with their personal challenges. considered one of them is that many times these steps accommodate human interaction, which is sluggish and susceptible to mistakes. Being capable of automate part, or all, of these steps would truly enrich how efficacious approaches are, and subsequently the first-class of the carrier provided with the aid of that utility.
  • one other element is the friction between structure and Operations teams.  A basic scenario the residence developers build utility drudgery in their construction ambiance, rush it to the operations team on the passage to test it (QA) and installation into a creation environment… and nothing works.The leading intuition for this is that these environments should exist by some means diverse. not only they might exercise distinct kernel versions (or even OS), but they might easily exist the exercise of distinctive library types to test modern performance. isolating utility dependencies from the running ambiance would convey superb advancements to this area.
  • after which there is the time-to-market ingredient, where continually it is IT who turns into the bottleneck for a modern provider, or function, to exist carried out in production. The smoother the mode to depart from evolution to creation, the less complicated and safer it could exist to accelerate the deployment of modern functionalities.
  • Wouldn’t or not it's first-class to absorb each teams, Dev and Ops, working together to alleviate these issues and hurry up the introduction of modern software capabilities to your functions? neatly, that's what DevOps is set. DevOps desires both groups to exist equally answerable for the whole lifecycle of software, so that it becomes less demanding, quicker and safer to deploy.

    one of the crucial ideas DevOps promotes is: why can’t Ops teams exercise the identical strategy to techniques as Dev makes exercise of for code? up to date construction makes exercise of Agile methodology for application, so why can’t they exercise that additionally for techniques?

    And despite the fact DevOps has very famous cultural ideas on how businesses deserve to change, during this weblog sequence they can focus on one of the approaches, applied sciences and options that DevOps teams exercise to enhance their each day work.

    Let’s birth at the start of everything, where builders… strengthen.

    New structure discovering Lab

    Please depart through my fresh Cisco studying Lab on ‘modern development’. it is concentrated on getting you begun from scratch: no traditional competencies on applications building, no up to now reserve in tools. i'll reserve you through every petite thing you deserve to understand microservices-based up to date applications, and how to installation your ambiance to rush an illustration application on your personal computer.

    you will learn the passage a latest microservices-based application look like, by using the superb illustration created by their colleague Hank Preston. not handiest it is a helpful illustration that he generously share, but additionally really helpful to vote in your favourite superhero!

    you'll learn how to build exercise of APIs to engage with microservices, including the distinct codecs and tools required for each task. You will besides create a brand modern person interface via Cisco Spark, and a bot to absorb interaction with!

    As a developer you are going to retract note how to modify your code and execute it. once your entire software is able you are going to learn to reserve up it so everybody can leverage what you absorb created (and respect your swag).

    and naturally, they are able to exercise Docker containers to implement microservices, so you will leverage everything potential obtained from my closing posts.

    through now you'll want to exist as excited as i'm, so let’s catch it on!  Any questions or feedback gladden let me exist cognizant of within the feedback participate under, or by means of Twitter or LinkedIn.


    Google's ‘Self-Destructing’ Emails, Cisco Pushes Spark Into WebEx, extra intelligence | existent questions with brain dumps

    woman reading the newspaper photo: Naren Morum

    Google is reportedly giving the web version of Gmail an immense remodel. Mountain View, Calif.-based mostly Google hasn't yet made an legitimate announcement about the release, but TechCrunch shared early previews of the modern inbox in addition to reporting that G Suite clients acquired a epistle previous this month asserting the brand modern peek might exist obtainable within the coming weeks, with the generic Gmail user agencies up-to-date later.

    in line with the message, the redesign will consist of a number of modern cell aspects, along with different features which absorb been mooted during the past like dozing emails, offline wait on and — one that is likely to exist a vast favourite among IT directors — self-destructing emails.

    different improvements comprehend Google Calendar entry directly from the Gmail interface, as well as an eventual update so they can enable users to store email in order that they are available offline as Google slowly phases out Chrome Apps. ultimately, whereas the Android and iOS clients absorb both benefitted from cloth Design enhancements, the internet customer’s interface hasn’t been up to date for years. This time, besides the fact that children, it's going to catch a massive design overhaul.

    youngsters, it's the ‘self-destruct’ characteristic that has been receiving essentially the most attention. in the compose window of Gmail, recipients will contemplate a miniature lock icon named confidential Mode which suggests the recipient received’t exist capable of ahead e mail content material, replica and paste, down load or print the e-mail.

    this is now not the first time Google has superior its provider. As early as 2014 it introduced Inbox, which allowed clients to streamline their inbox and ensure probably the most famous emails landed within the privilege area. Microsoft answered with the addition of concentrated Inbox to Outlook. within the conclusion, it's clients that win and will proceed to accomplish that as both Google and Microsoft battle it out for supremacy in yet an additional belt of competitors in the productiveness area.

    Dropbox Boosts Collaboration with showcase

    San Francisco-based Dropbox  may well exist value $10 billion, but it surely nevertheless has to hold its users happy. As participate of that effort, this week the industry pushed exhibit into prevalent availability for everything Dropbox enterprise superior and commercial enterprise teams.

    Dropbox launched showcase final tumble as a visible portfolio-sharing device that made it workable to participate a bunch of files, together with giant images, headers and prosperous previews, as an alternative of providing static links. Now, on the groundwork of consumer feedback it is additionally adding improvements.

    “over the eventual few months, we’ve been gathering feedback from Dropbox industry teams with early access to disclose off. Their input has helped us refine disclose off and improve it with the brand modern functionality we’re introducing for each crew admins and showcase creators," the enterprise mentioned in an announcement. the brand modern functionality enables administrators to now manipulate crew-extensive settings, permit external sharing, and set default download permissions for viewers of group’s showcases. among the many different additions is drag-and-drop uploads, recipient previews and the capacity to reuse ancient showcases.

    Dropbox is just one of many file sync and participate functions available in the marketplace in the meanwhile. What makes the desirable choices stand out is their ease of exercise and speed. With exhibit, Dropbox is adding another string to its enterprise bow, making it much more fascinating to predominant corporations.

    Cisco Introduces WebEx teams

    San Jose, Calif.-based Cisco changed into besides diligent this week, with the announcement it will fold its collaboration platform Spark into WebEx to create a modern ecosystem of functions. Spark is Cisco's cloud-based collaboration suite for groups which provides rig to create, meet, message, name, whiteboard and share. WebEx is Cisco’s on-demand collaboration, assembly, internet conferencing and video conferencing utility.

    The effect is a brand modern WebEx meetings application and a WebEx-enabled Spark utility — now called WebEx groups. WebEx groups pulls together everything of the collaboration points in Spark and puts them alongside aspects from the WebEx conferencing platform, equivalent to whiteboarding, persistent messaging, primary visitor access, and content material sharing.

    Cisco explained the move in a press release, pointing out that pulling the two together would influence in a complete integration of technology across structures, complete with a common cloud again conclude and user experience. The statement continued, “we are putting everything their award-profitable video instruments onto this newly converged platform. And we’re adding a brand modern hardware machine that turns any drudgery space with a television privilege into a WebEx room. They didn’t halt there. We’re making every thing simpler to purchase. And we’re continuing to follow laptop studying and synthetic intelligence so that you can dramatically improve meetings as they exist cognizant of them these days.” 

    The result is any house with a television may exist turned into a WebEx room. no matter if any of the other players in the space like Microsoft with its Skype for company can equal this when it comes to computing punch and functionality remains to exist considered.

    Akumina adds indigenous cell

    in the meantime, Nashua, N.H.-based mostly digital residence of drudgery platform provider Akumina has upgraded its product portfolio with the introduction of points that carry assist for indigenous enterprise mobile apps. These modern enhancements allow personnel to access commandeer industry purposes and tips at any time, in any language, and on any device — either through customary responsive design or by means of indigenous cellular app options on the Apple iOS and Google Android systems.

    The Akumina digital workplace solution is built on proper of office 365 and ships with profound integrations to applications like, Workday, Oracle Cloud, SAP, ServiceNow and others.

    AccuSystems upgrades DMS

    ultimately this week, Pueblo, Colo.-based AccuSystems has added AccuAccount 2018, the newest edition of its doc management device, which comes with a newly designed interface. the brand modern UI  aims to build it more straightforward to manipulate customer assistance, scan and index captious files.

    AccuAccount is designed especially to wait on the management of commercial loan portfolios and credit score information. It gives integration to more than 30 core banking techniques. It additionally simplifies doc monitoring and exception management, removing the need for manual ticklers and spreadsheets.

    642-655 WAASFE-Wide belt Application Services for realm Engineers

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    Cloning and belt constitution of the mammalian splicing ingredient U2AF | existent questions with brain dumps

  • 1.

    eco-friendly, M. R. A. Rev phone Biol. 7, 559–599 (1991).

  • 2.

    Maniatis, T. & Reed, R. Nature 325, 673–678 (1987).

  • 3.

    Sharp, P. A. Science 235, 766–771 (1987).

  • 4.

    Guthrie, C. Science 253, 157–163 (1991).

  • 5.

    Barabino, S. M. L., Blencowe, B. J., Ryder, U., Sproat, B. S. & Lamond, A. I. cell 63, 293–302 (1990).

  • 6.

    Kramer, A. & Utans, U. EMBO J. 10, 1503–1510 (1991).

  • 7.

    Ruskin, B., Zamore, P. D. & green, M. R. mobilephone 52, 207–219 (1988).

  • eight.

    Zamore, P. D. & eco-friendly, M. R. Proc. natn Acad. Sci. united states of americaA. 86, 9243–9247 (1989).

  • 9.

    Zamore, P. D. & green, M. R. EMBO J. 10, 207–214 (1991).

  • 10.

    Gardiner-backyard, M. & Frommer, M. J. molec. Biol. 196, 261–282 (1987).

  • eleven.

    Theissen, H. et al. EMBO J. 5, 3209–3217 (1986).

  • 12.

    query, C. C. & Keene, J. D. telephone fifty one, 211–220 (1987).

  • 13.

    Etzerodt, M. et al. EMBO J. 7, 4311–4321 (1988).

  • 14.

    Mancebo, R., Lo, P. C. H. & Mount, S. M. Molec. telephone. Biol. 10, 2492–2502 (1990).

  • 15.

    Ge, H., Zuo, P. & Manley, J. L. telephone 66, 373–382 (1991).

  • sixteen.

    Krainer, A. R., Mayeda, A., Kozak, D. & Binns, G. phone 66, 383–394 (1991).

  • 17.

    Boggs, R. T., Gregor, P., Idriss, S., Belote, J. M. & McKeown, M. phone 50, 739–747 (1987).

  • 18.

    Amrein, k. Gorman, M. & Nöthiger, R. cell fifty five, 1025–1035 (1988).

  • 19.

    Goralski, T. J., Edström, J-E. & Baker, B. S. cell fifty six, 1011–1018 (1989).

  • 20.

    Voelker, R. A., Gibson, W., Graves, J. P., Sterling, J. F. & Eisenberg, M. T. Molec. phone. Biol. 11, 894–905 (1991).

  • 21.

    Chou, T-B., Zachar, Z. & Bingham, P. M. EMBO J. 6, 4095–4104.

  • 22.

    Dreyfus, G., Swanson, M. S. & Pin̄ol-Roma, S. tendencies biochem. Sci. 13, 86–ninety one (1988).

  • 23.

    Kenan, D. J., question, C. C. & Keene, J. D. developments biochem Sci. sixteen, 214–220 (1991).

  • 24.

    Garcia-Blanco, M. A., Jamison, S. & Sharp, P. A. Genes Dev. 3, 1874–1886 (1989).

  • 25.

    Zamore, P. D., Zapp, M. L. & green, M. R. Nature 348, 485–486 (1991).

  • 26.

    Scherly, D., Dathan, N. A., Boelens, W., van Venrooij, W. J. & Mattaj, I. W. EMBO J. 9, 3675–3681.

  • 27.

    Reed, R. Genes Dev. 3, 2113–2123 (1989).

  • 28.

    Mullen, M. P., Smith, C. W. J., Patton, J. G. & Nadal-Ginard, B. Genes Dev. 5, 642–655 (1991).

  • 29.

    Smith, C. W. J., Porro, E., Patton, J. G. & Nadal-Ginard, B. Nature 342, 243–247 (1989).

  • 30.

    Zillmann, M., Zapp, M. L. & Berget, S. M. Molec. cellphone. Biol. eight, 814–821 (1988).

  • 31.

    Bindereif, A. & green, M. R. EMBO J. 6, 2415–2424 (1987).

  • 32.

    Li, H. & Bingham, P. M. cellphone, sixty seven, 335–342 (1991).

  • 33.

    Carmo-Fonseca M. et al. EMBO J. 10, 195–207 (1990).

  • 34.

    Smith, C. W. J., Patton, J. G. & Nadal-Ginard, B. A. Rev. Genet. 23, 527–577 (1989).

  • 35.

    Baker, B. S. Nature 340, 521–524 (1989).

  • 36.

    Hedley, M. L. & Maniatis T. phone sixty five, 579–586 (1991).

  • 37.

    Aebersold, R. H., Leavitt, J., Saavedra, R. A., Hood, L. E. & Kent, S. B. H. Proc. natn. Acad. Sci. u.s.A. eighty four, 6970–6974 (1987).

  • 38.

    Smith, D. B. & Johnson, ok. S. Gene 67, 31–40 (1988).

  • 39.

    Lin, Y. S. & green, M. R. mobilephone sixty four, 971–981 (1991).

  • Drugging the undruggable RAS: Mission viable? | existent questions with brain dumps

  • 1.

    Cox, A. D. & Der, C. J. RAS background: The saga continues. miniature GTPases 1, 2–27 (2010).

  • 2.

    Vogelstein, B. et al. melanoma genome landscapes. Science 339, 1546–1558 (2013).

  • three.

    Thompson, H. US country wide melanoma Institute's modern RAS project targets an ancient foe. Nature Med. 19, 949–950 (2013).

  • 4.

    Berndt, N., Hamilton, A. D. & Sebti, S. M. targeting protein prenylation for melanoma therapy. Nature Rev. cancer eleven, 775–791 (2011).

  • 5.

    Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to advertise chromosomal instability and greatly metastatic pancreatic ductal adenocarcinoma in mice. cancer cell 7, 469–483 (2005).

  • 6.

    Ji, H. et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448, 807–810 (2007).

  • 7.

    Haigis, ok. M. et al. Differential effects of oncogenic KRAS and NRAS on proliferation, differentiation and tumor progression in the colon. Nature Genet. 40, 600–608 (2008).

  • 8.

    Brummelkamp, T. R., Bernards, R. & Agami, R. stable suppression of tumorigenicity through virus-mediated RNA interference. melanoma cell 2, 243–247 (2002).

  • 9.

    Lim, k. H. & Counter, C. M. reduction within the requirement of oncogenic RAS signaling to activation of PI3K/AKT pathway throughout tumor maintenance. cancer telephone 8, 381–392 (2005).

  • 10.

    Singh, A. et al. A gene expression signature associated with “KRAS addiction” exhibits regulators of EMT and tumor telephone survival. cancer mobile 15, 489–500 (2009).

  • 11.

    Chin, L. et al. benchmark function for oncogenic RAS in tumour preservation. Nature 400, 468–472 (1999).

  • 12.

    Collins, M. A. et al. Metastatic pancreatic cancer is contingent on oncogenic KRAS in mice. PLoS ONE 7, e49707 (2012).

  • 13.

    Fisher, G. H. et al. Induction and apoptotic regression of lung adenocarcinomas by means of law of a KRAS transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15, 3249–3262 (2001).

  • 14.

    Kwong, L. N. et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nature Med. 18, 1503–1510 (2012).

  • 15.

    Ying, H. et al. Oncogenic KRAS keeps pancreatic tumors via legislation of anabolic glucose metabolism. cellphone 149, 656–670 (2012). This study indicates, in an autochthonous model, that oncogenic KRAS is required for pancreatic tumour preservation, in participate via its position in reprogramming anabolic glucose metabolism.

  • 16.

    Bos, J. L., Rehmann, H. & Wittinghofer, A. GEFs and GAPs: famous facets within the wield of miniature G proteins. telephone 129, 865–877 (2007).

  • 17.

    Stephen, A. G., Esposito, D., Bagni, R. okay. & McCormick, F. Dragging RAS again within the ring. cancer cellphone 25, 272–281 (2014).

  • 18.

    Ahearn, I. M., Haigis, ok., Bar-Sagi, D. & Philips, M. R. Regulating the regulator: publish-translational amendment of RAS. Nature Rev. Mol. mobile Biol. 13, 39–51 (2012).

  • 19.

    Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J. & Brown, M. S. Inhibition of purified p21ras farnesyl:protein transferase by using Cys-AAX tetrapeptides. phone 62, eighty one–88 (1990).

  • 20.

    James, G. L., Goldstein, J. L. & Brown, M. S. Polylysine and CVIM sequences of KRASB ordain specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J. Biol. Chem. 270, 6221–6226 (1995).

  • 21.

    Whyte, D. B. et al. k- and N-RAS are geranylgeranylated in cells handled with farnesyl protein transferase inhibitors. J. Biol. Chem. 272, 14459–14464 (1997).

  • 22.

    Rowell, C. A., Kowalczyk, J. J., Lewis, M. D. & Garcia, A. M. Direct demonstration of geranylgeranylation and farnesylation of Ki-RAS in vivo. J. Biol. Chem. 272, 14093–14097 (1997).

  • 23.

    Vigil, D., Cherfils, J., Rossman, ok. L. & Der, C. J. RAS superfamily GEFs and GAPs: validated and tractable goals for cancer remedy? Nature Rev. cancer 10, 842–857 (2010).

  • 24.

    grant, B. J. et al. Novel allosteric websites on RAS for lead era. PLoS ONE 6, e25711 (2011).

  • 25.

    Buhrman, G. et al. evaluation of binding web site scorching spots on the floor of RAS GTPase. J. Mol. Biol. 413, 773–789 (2011).

  • 26.

    Wang, W., Fang, G. & Rudolph, J. RAS inhibition via direct RAS binding — is there a direction ahead? Bioorg. Med. Chem. Lett. 22, 5766–5776 (2012).

  • 27.

    Taveras, A. G. et al. RAS oncoprotein inhibitors: the invention of amazing, RAS nucleotide exchange inhibitors and the structural resolution of a drug-protein complicated. Bioorg. Med. Chem. 5, a hundred twenty five–133 (1997).

  • 28.

    Peri, F. et al. Design, synthesis and organic comparison of sugar-derived RAS inhibitors. Chembiochem 6, 1839–1848 (2005).

  • 29.

    Herrmann, C. et al. Sulindac sulfide inhibits RAS signaling. Oncogene 17, 1769–1776 (1998).

  • 30.

    Waldmann, H. et al. Sulindac-derived RAS pathway inhibitors goal the RAS–RAF interaction and downstream effectors in the RAS pathway. Angew. Chem. Int. Ed Engl. forty three, 454–458 (2004).

  • 31.

    Karaguni, I. M. et al. the brand modern sulindac by-product IND 12 reverses RAS-prompted phone transformation. melanoma Res. 62, 1718–1723 (2002).

  • 32.

    Karaguni, I. M. et al. modern indene-derivatives with anti-proliferative houses. Bioorg. Med. Chem. Lett. 12, 709–713 (2002).

  • 33.

    Gonzalez-Perez, V. et al. Genetic and practical characterization of putative RAS/RAF interplay inhibitors in C. elegans and mammalian cells. J. Mol. signal. 5, 2 (2010).

  • 34.

    Kato-Stankiewicz, J. et al. Inhibitors of RAS/RAF1 interplay recognized by passage of two-hybrid screening revert RAS-elegant transformation phenotypes in human melanoma cells. Proc. Natl Acad. Sci. us of a ninety nine, 14398–14403 (2002).

  • 35.

    Rosnizeck, I. C. et al. Stabilizing a vulnerable binding condition for effectors within the human RAS protein by passage of cyclen complexes. Angew. Chem. Int. Ed Engl. forty nine, 3830–3833 (2010).

  • 36.

    Patgiri, A., Yadav, k. k., Arora, P. S. & Bar-Sagi, D. An orthosteric inhibitor of the RAS–SOS interplay. Nature Chem. Biol. 7, 585–587 (2011).

  • 37.

    Chang, Y. S. et al. Stapled α-helical peptide drug construction: a sturdy twin inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc. Natl Acad. Sci. u . s . 110, E3445–E3454 (2013).

  • 38.

    Maurer, T. et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide alternate exercise. Proc. Natl Acad. Sci. country 109, 5299–5304 (2012).

  • 39.

    solar, Q. et al. Discovery of miniature molecules that bind to KRAS and inhibit SOS-mediated activation. Angew. Chem. Int. Ed Engl. 51, 6140–6143 (2012).

  • forty.

    Shima, F. et al. In silico discovery of small-molecule RAS inhibitors that monitor antitumor endeavor by means of blocking off the RAS-effector interaction. Proc. Natl Acad. Sci. u . s . 110, 8182–8187 (2013).

  • 41.

    Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A. & Shokat, okay. M. KRAS (G12C) inhibitors allosterically wield GTP affinity and effector interactions. Nature 503, 548–551 (2013). This study describes a novel mode to selectively target RAS-G12C by covalently attaching miniature molecules to the cysteine at residue 12.

  • forty two.

    Chen, k. X. et al. A novel sort of highly wonderful irreversible hepatitis C virus NS5B polymerase inhibitors. J. Med. Chem. fifty five, 2089–2101 (2012).

  • forty three.

    Ward, R. A. et al. structure- and reactivity-based mostly construction of covalent inhibitors of the activating and gatekeeper mutant types of the epidermal multiply factor receptor (EGFR). J. Med. Chem. fifty six, 7025–7048 (2013).

  • 44.

    Lim, S. M. et al. Therapeutic concentrated on of oncogenic KRAS by passage of a covalent catalytic site inhibitor. Angew. Chem. Int. Ed Engl. fifty three, 199–204 (2014). This examine describes an mode to selectively target G12C mutant RAS by passage of covalently attaching a nucleotide analogue.

  • 45.

    Burns, M. C. et al. strategy for focused on RAS with miniature molecules that spark off SOS-mediated nucleotide exchange. Proc. Natl Acad. Sci. usa 111, 3401–3406 (2014). in this paper, compounds were described that activate SOS-mediated nucleotide trade and paradoxically inhibit downstream RAS signalling.

  • 46.

    Chen, X., Makarewicz, J. M., Knauf, J. A., Johnson, L. ok. & Fagin, J. A. Transformation via HrasG12V is continuously associated with mutant allele reproduction positive aspects and is reversed by passage of farnesyl transferase inhibition. Oncogene (2013).

  • 47.

    Liu, M. et al. targeting the protein prenyltransferases successfully reduces tumor construction in mice with KRAS-precipitated lung cancer. Proc. Natl Acad. Sci. usa 107, 6471–6476 (2010).

  • 48.

    Marom, M. et al. Selective inhibition of RAS-stylish cellphone multiply with the aid of farnesylthiosalisylic acid. J. Biol. Chem. 270, 22263–22270 (1995).

  • 49.

    Gana-Weisz, M. et al. The RAS antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. Biochem. Biophys. Res. Commun. 239, 900–904 (1997).

  • 50.

    Haklai, R. et al. Dislodgment and accelerated degradation of RAS. Biochemistry 37, 1306–1314 (1998).

  • fifty one.

    Makovski, V., Haklai, R. & Kloog, Y. Farnesylthiosalicylic acid (salirasib) inhibits RHEB in TSC2-null ELT3 cells: a workable remedy for lymphangioleiomyomatosis. Int. J. melanoma 130, 1420–1429 (2012).

  • fifty two.

    McMahon, L. P., Yue, W., Santen, R. J. & Lawrence, J. C. Jr. Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) pastime both in cells and in vitro by merchandising dissociation of the mTOR-Raptor complicated. Mol. Endocrinol. 19, a hundred seventy five–183 (2005).

  • 53.

    Hanker, A. B. et al. Differential requirement of CAAX-mediated posttranslational processing for RHEB localization and signaling. Oncogene 29, 380–391 (2010).

  • 54.

    Weisz, B. et al. a brand modern functional RAS antagonist inhibits human pancreatic tumor boom in nude mice. Oncogene 18, 2579–2588 (1999).

  • 55.

    Haklai, R., Elad-Sfadia, G., Egozi, Y. & Kloog, Y. Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. cancer Chemother. Pharmacol. 61, 89–96 (2008).

  • fifty six.

    Laheru, D. et al. built-in preclinical and clinical structure of S-trans, trans-farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. invest. modern medication 30, 2391–2399 (2012).

  • fifty seven.

    Wahlstrom, A. M. et al. Rce1 deficiency hurries up the evolution of KRAS-induced myeloproliferative disease. Blood 109, 763–768 (2007).

  • 58.

    Wahlstrom, A. M. et al. Inactivating Icmt ameliorates KRAS-brought on myeloproliferative disorder. Blood 112, 1357–1365 (2008).

  • 59.

    court docket, H. et al. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-pushed pancreatic neoplasia by passage of Notch suppression. J. Clin. build investments. 123, 4681–4694 (2013).

  • 60.

    Majmudar, J. D. et al. Amide-modified prenylcysteine based mostly ICMT inhibitors: constitution–endeavor relationships, kinetic analysis and mobile characterization. Bioorg. Med. Chem. 20, 283–295 (2012).

  • 61.

    Manandhar, S. P., Hildebrandt, E. R. & Schmidt, W. okay. Small-molecule inhibitors of the RCE1P CAAX protease. J. Biomol. disclose 12, 983–993 (2007).

  • 62.

    iciness-Vann, A. M. et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor undertaking in cancer cells. Proc. Natl Acad. Sci. usa 102, 4336–4341 (2005).

  • 63.

    Chiu, V. k. et al. RAS signalling on the endoplasmic reticulum and the Golgi. Nature telephone Biol. 4, 343–350 (2002).

  • 64.

    Cuiffo, B. & Ren, R. Palmitoylation of oncogenic NRAS is simple for leukemogenesis. Blood one hundred fifteen, 3598–3605 (2010).

  • 65.

    Swarthout, J. T. et al. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-RAS. J. Biol. Chem. 280, 31141–31148 (2005).

  • sixty six.

    Goodwin, J. S. et al. Depalmitoylated RAS traffics to and from the Golgi complicated via a nonvesicular pathway. J. phone Biol. a hundred and seventy, 261–272 (2005).

  • sixty seven.

    Rocks, O. et al. The palmitoylation rig is a spatially organizing gadget for peripheral membrane proteins. cell 141, 458–471 (2010).

  • 68.

    Rocks, O. et al. An acylation cycle regulates localization and endeavor of palmitoylated RAS isoforms. Science 307, 1746–1752 (2005).

  • 69.

    Dekker, F. J. et al. Small-molecule inhibition of APT1 impacts RAS localization and signaling. Nature Chem. Biol. 6, 449–456 (2010).

  • 70.

    Resh, M. D. targeting protein lipidation in disorder. developments Mol. Med. 18, 206–214 (2012).

  • 71.

    Bivona, T. G. et al. PKC regulates a farnesyl-electrostatic activate KRAS that promotes its affiliation with BCL-XL on mitochondria and induces apoptosis. Mol. mobile 21, 481–493 (2006). This study recognized a kinase-pushed phosphorylation that regulates KRAS4B membrane association, subcellular localization and oncogenic homes.

  • seventy two.

    Sung, P. J. et al. Phosphorylated KRAS limits telephone survival by means of blocking BCL-XL sensitization of inositol trisphosphate receptors. Proc. Natl Acad. Sci. u . s . a hundred and ten, 20593–20598 (2013).

  • 73.

    Kollar, P., Rajchard, J., Balounova, Z. & Pazourek, J. Marine herbal products: bryostatins in preclinical and medical experiences. Pharm. Biol. fifty two, 237–242 (2013).

  • seventy four.

    Barcelo, C. et al. Phosphorylation at Ser181 of oncogenic KRAS is required for tumor boom. melanoma Res. 74, 1190–1199 (2013).

  • seventy five.

    Lim, okay. H., Ancrile, B. B., Kashatus, D. F. & Counter, C. M. Tumour maintenance is mediated via eNOS. Nature 452, 646–649 (2008).

  • 76.

    Lampson, B. L. et al. focused on eNOS in pancreatic cancer. cancer Res. seventy two, 4472–4482 (2012).

  • 77.

    Zhang, H., Constantine, R., Frederick, J. M. & Baehr, W. The prenyl-binding protein PrBP/δ: a chaperone collaborating in intracellular trafficking. vision Res. 75, 19–25 (2012).

  • seventy eight.

    Chandra, A. et al. The GDI-like solubilizing aspect PDEδ sustains the spatial organization and signalling of RAS family unit proteins. Nature cell Biol. 14, 148–158 (2012).

  • seventy nine.

    Zimmermann, G. et al. miniature molecule inhibition of the KRAS–PDEδ interplay impairs oncogenic KRAS signalling. Nature 497, 638–642 (2013). This peek at recognized a miniature molecule that can disrupt KRAS4B affiliation with a protein chaperone, altering KRAS4B membrane trafficking and cellular activity.

  • eighty.

    Philips, M. R. RAS hitchhikes on PDE6δ. Nature phone Biol. 14, 128–129 (2012).

  • eighty one.

    Jura, N., Scotto-Lavino, E., Sobczyk, A. & Bar-Sagi, D. Differential modification of RAS proteins via ubiquitination. Mol. mobile 21, 679–687 (2006).

  • eighty two.

    Sasaki, A. T. et al. Ubiquitination of KRAS enhances activation and enables binding to pick downstream effectors. Sci. sign four, ra13 (2011).

  • eighty three.

    Sumita, k. et al. Degradation of activated KRAS orthologue by means of KRAS-specific lysine residues is required for cytokinesis. J. Biol. Chem. 289, 3950–3959 (2014).

  • 84.

    Yang, M. H. et al. HDAC6 and SIRT2 adjust the acetylation condition and oncogenic activity of mutant KRAS. Mol. cancer Res. eleven, 1072–1077 (2013).

  • eighty five.

    Baines, A. T., Xu, D. & Der, C. J. Inhibition of RAS for melanoma remedy: the quest continues. Future Med. Chem. three, 1787–1808 (2011).

  • 86.

    Blasco, R. B. et al. CRAF, but not BRAF, is elementary for structure of KRAS oncogene-pushed non-small phone lung carcinoma. melanoma cellphone 19, 652–663 (2011).

  • 87.

    Collisson, E. A. et al. A principal role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. cancer Discov. 2, 685–693 (2012).

  • 88.

    Roskoski, R. Jr. ERK1/2 MAP kinases: constitution, function, and regulation. Pharmacol. Res. sixty six, 105–143 (2012).

  • 89.

    Lyons, J. F., Wilhelm, S., Hibner, B. & Bollag, G. Discovery of a novel RAF kinase inhibitor. Endocr. Relat. melanoma 8, 219–225 (2001).

  • 90.

    Wilhelm, S. M. et al. BAY forty three–9006 exhibits wide spectrum oral antitumor recreation and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases worried in tumor progression and angiogenesis. melanoma Res. sixty four, 7099–7109 (2004).

  • 91.

    Lito, P., Rosen, N. & Solit, D. B. Tumor adaptation and resistance to RAF inhibitors. Nature Med. 19, 1401–1409 (2013).

  • 92.

    Hatzivassiliou, G. et al. RAF inhibitors best wild-classification RAF to prompt the MAPK pathway and enhance increase. Nature 464, 431–435 (2010).

  • ninety three.

    Heidorn, S. J. et al. Kinase-lifeless BRAF and oncogenic RAS cooperate to drive tumor evolution via CRAF. cellphone a hundred and forty, 209–221 (2010).

  • 94.

    Poulikakos, P. I., Zhang, C., Bollag, G., Shokat, okay. M. & Rosen, N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-classification BRAF. Nature 464, 427–430 (2010). References ninety two–94 decided that BRAF inhibitors trigger RAS-activation-based RAF dimerization and ERK activation rather than inactivation.

  • 95.

    hall-Jackson, C. A. et al. Paradoxical activation of RAF by passage of a novel RAF inhibitor. Chem. Biol. 6, 559–568 (1999).

  • 96.

    Oberholzer, P. A. et al. RAS mutations are linked to the construction of cutaneous squamous telephone tumors in sufferers treated with RAF inhibitors. J. Clin. Oncol. 30, 316–321 (2012).

  • 97.

    Su, F. et al. RAS mutations in cutaneous squamous-telephone carcinomas in patients handled with BRAF inhibitors. N. Engl. J. Med. 366, 207–215 (2012).

  • ninety eight.

    Freeman, A. k., Ritt, D. A. & Morrison, D. okay. results of RAF dimerization and its inhibition on common and disorder-linked RAF signaling. Mol. cell 49, 751–758 (2013).

  • 99.

    Gilmartin, A. G. et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with benign pharmacokinetic homes for sustained in vivo pathway inhibition. Clin. cancer Res. 17, 989–1000 (2011).

  • 100.

    Engelman, J. A. et al. helpful exercise of PI3K and MEK inhibitors to deal with mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Med. 14, 1351–1356 (2008).

  • a hundred and one.

    Hatzivassiliou, G. et al. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-pushed cancers. Nature 501, 232–236 (2013).

  • 102.

    Ishii, N. et al. greater inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF exercise. melanoma Res. 73, 4050–4060 (2013).

  • 103.

    Duncan, J. S. et al. Dynamic reprogramming of the kinome in keeping with targeted MEK inhibition in triple-bad breast cancer. telephone 149, 307–321 (2012). This examine utilized a kinome-large approach to identify MEK-inhibitor-induced compensatory pursuits that can then exist targeted to avoid de novo resistance mechanisms.

  • 104.

    Little, A. S. et al. Amplification of the riding oncogene, KRAS or BRAF, underpins obtained resistance to MEK1/2 inhibitors in colorectal cancer cells. Sci. signal. 4, ra17 (2011).

  • one hundred and five.

    Bollag, G. et al. clinical efficacy of a RAF inhibitor wants vast goal blockade in BRAF-mutant melanoma. Nature 467, 596–599 (2010).

  • 106.

    Morris, E. J. et al. Discovery of a novel ERK inhibitor with recreation in fashions of got resistance to BRAF and MEK inhibitors. melanoma Discov. three, 742–750 (2013).

  • 107.

    Gupta, S. et al. Binding of RAS to phosphoinositide three-kinase p110 α is required for RAS-driven tumorigenesis in mice. phone 129, 957–968 (2007).

  • 108.

    Castellano, E. et al. Requirement for interplay of PI3-kinase p110α with RAS in lung tumor preservation. cancer mobilephone 24, 617–630 (2013).

  • 109.

    Ebi, H. et al. Receptor tyrosine kinases exert preeminent wield over PI3K signaling in human KRAS mutant colorectal cancers. J. Clin. build investments. 121, 4311–4321 (2011).

  • 110.

    Britten, C. D. PI3K and MEK inhibitor combinations: analyzing the proof in selected tumor forms. melanoma Chemother. Pharmacol. seventy one, 1395–1409 (2013).

  • 111.

    Bodemann, B. O. & White, M. A. RAL GTPases and melanoma: linchpin aid of the tumorigenic platform. Nature Rev. cancer eight, 133–140 (2008).

  • 112.

    Neel, N. F. et al. The RALGEF–RAL effector signaling network: the road less traveled for anti-RAS drug discovery. Genes melanoma 2, 275–287 (2011).

  • 113.

    Gonzalez-Garcia, A. et al. RALGDS is required for tumor formation in a model of skin carcinogenesis. melanoma telephone 7, 219–226 (2005).

  • 114.

    Vigil, D. et al. Aberrant overexpression of the RGL2 RAL miniature GTPase-particular guanine nucleotide change ingredient promotes pancreatic melanoma growth via RAL-based and RAL-impartial mechanisms. J. Biol. Chem. 285, 34729–34740 (2010).

  • a hundred and fifteen.

    Lim, ok. H. et al. Divergent roles for RALA and RALB in malignant multiply of human pancreatic carcinoma cells. Curr. Biol. 16, 2385–2394 (2006).

  • 116.

    Peschard, P. et al. Genetic deletion of RALA and RALB miniature GTPases displays redundant functions in structure and tumorigenesis. Curr. Biol. 22, 2063–2068 (2012).

  • 117.

    Wu, J. C. et al. Identification of V23RALA-Ser194 as a famous mediator for Aurora-A-triggered mobile motility and transformation via miniature pool expression screening. J. Biol. Chem. 280, 9013–9022 (2005).

  • 118.

    Lim, k. H. et al. Aurora-A phosphorylates, prompts, and relocalizes the miniature GTPase RalA. Mol. telephone. Biol. 30, 508–523 (2010).

  • 119.

    Wang, H. et al. Phosphorylation of RALB is essential for bladder cancer telephone boom and metastasis. melanoma Res. 70, 8760–8769 (2010).

  • one hundred twenty.

    Martin, T. D., Mitin, N., Cox, A. D., Yeh, J. J. & Der, C. J. Phosphorylation via protein kinase Cα regulates RALB miniature GTPase protein activation, subcellular localization, and effector utilization. J. Biol. Chem. 287, 14827–14836 (2012).

  • 121.

    Chien, Y. et al. RALB GTPase-mediated activation of the IκB family kinase TBK1 couples hereditary immune signaling to tumor phone survival. cell 127, 157–one hundred seventy (2006).

  • 122.

    Martin, T. D. et al. RAL and RHEB GTPase activating proteins combine mTOR and GTPase signaling in ageing, autophagy, and tumor mobile invasion. Mol. mobilephone fifty three, 209–220 (2014).

  • 123.

    Malliri, A. et al. Mice deficient in the RAC activator TIAM1 are proof against RAS-triggered epidermis tumours. Nature 417, 867–871 (2002).

  • 124.

    Lambert, J. M. et al. TIAM1 mediates RAS activation of RAC by a PI(3)ok-impartial mechanism. Nature mobilephone Biol. 4, 621–625 (2002).

  • 125.

    Welch, H. C. et al. P-REX1, a PtdIns(three,four,5)P3- and Gβγ-regulated guanine-nucleotide exchange component for RAC. mobile 108, 809–821 (2002).

  • 126.

    Hodis, E. et al. A landscape of driver mutations in melanoma. cell one hundred fifty, 251–263 (2012).

  • 127.

    Krauthammer, M. et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nature Genet. forty four, 1006–1014 (2012).

  • 128.

    Kissil, J. L. et al. Requirement for RAC1 in a KRAS precipitated lung cancer within the mouse. melanoma Res. sixty seven, 8089–8094 (2007).

  • 129.

    Heid, I. et al. Early requirement of RAC1 in a mouse model of pancreatic cancer. Gastroenterol 141, 719–730.e7 (2011).

  • a hundred thirty.

    Cardama, G. A. et al. Preclinical construction of novel RAC1–GEF signaling inhibitors the exercise of a rational design approach in highly aggressive breast melanoma telephone lines. Anticancer agents Med. Chem. 14, 840–851 (2013).

  • 131.

    Gao, Y., Dickerson, J. B., Guo, F., Zheng, J. & Zheng, Y. Rational design and characterization of a RAC GTPase-particular miniature molecule inhibitor. Proc. Natl Acad. Sci. country one zero one, 7618–7623 (2004).

  • 132.

    Chow, H. Y. et al. p21-activated kinase 1 is required for efficient tumor formation and evolution in a RAS-mediated skin cancer model. melanoma Res. 72, 5966–5975 (2012).

  • 133.

    Fritsch, R. et al. RAS and RHO families of GTPases at once modify distinct phosphoinositide 3-kinase isoforms. mobile 153, 1050–1063 (2013).

  • 134.

    Chan, J. J. & Katan, M. PLCε and the RASSF family unit in tumour suppression and other features. Adv. Biol. Regul. fifty three, 258–279 (2013).

  • 135.

    Hartman, J. L. 4th, Garvik, B. & Hartwell, L. ideas for the buffering of genetic model. Science 291, 1001–1004 (2001).

  • 136.

    Kaelin, W. G. Jr. The thought of synthetic lethality in the context of anticancer therapy. Nature Rev. melanoma 5, 689–698 (2005).

  • 137.

    Hanahan, D. & Weinberg, R. A. The hallmarks of melanoma. phone 100, fifty seven–70 (2000).

  • 138.

    Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next era. telephone a hundred and forty four, 646–674 (2011).

  • 139.

    Luo, J., Solimini, N. L. & Elledge, S. J. ideas of melanoma remedy: oncogene and non-oncogene dependancy. mobile 136, 823–837 (2009).

  • one hundred forty.

    Yu, B. & Luo, J. in Inhibitors of the RAS Superfamily G-proteins, half B. (eds. Tamanoi, F. & Der, C. J.) 201–215 (tutorial Press, 2013).

  • 141.

    Cox, A. D. & Der, C. J. The murky facet of RAS: law of apoptosis. Oncogene 22, 8999–9006 (2003).

  • 142.

    Kumar, M. S. et al. The GATA2 transcriptional community is requisite for RAS oncogene-driven non-small cellphone lung melanoma. cell 149 642–655 (2012).

  • 143.

    Luo, J. et al. A genome-large RNAi panoply identifies multiple synthetic lethal interactions with the RAS oncogene. mobilephone 137, 835–848 (2009). here's one among a few reviews describing gigantic-scale RNAi screens aiming to identify synthetic deadly companions of the KRAS oncogene.

  • a hundred and forty four.

    Barbie, D. A. et al. Systematic RNA interference exhibits that oncogenic KRAS-pushed cancers require TBK1. Nature 462, 108–112 (2009).

  • one hundred forty five.

    Steckel, M. et al. selection of synthetic deadly interactions in KRAS oncogene-dependent melanoma cells reveals novel therapeutic targeting ideas. telephone Res. 22, 1227–1245 (2012).

  • 146.

    Carretero, J. et al. Integrative genomic and proteomic analyses establish targets for LKB1-poor metastatic lung tumors. melanoma telephone 17, 547–559 (2010).

  • 147.

    Kim, H. S. et al. Systematic identification of molecular subtype-selective vulnerabilities in non-small-mobile lung cancer. telephone 155, 552–566 (2013).

  • 148.

    Garraway, L. A. & marketers, W. R. Lineage dependency and lineage-survival oncogenes in human melanoma. Nature Rev. melanoma 6, 593–602 (2006).

  • 149.

    Kapoor, A. et al. YAP1 activation enables bypass of oncogenic KRAS dependancy in pancreatic cancer. telephone 158, 185–197 (2014). This analyze, along with reference 150, identified a novel pass mechanism that could render KRAS-addicted cancer cells immune to RAS-targeted remedy.

  • one hundred fifty.

    Shao, D. D. et al. KRAS and YAP1 converge to alter EMT and tumor survival. mobilephone 158, 171–184 (2014).

  • 151.

    Cheung, H. W. et al. Systematic investigation of genetic vulnerabilities throughout melanoma mobile lines displays lineage-particular dependencies in ovarian cancer. Proc. Natl Acad. Sci. united states 108, 12372–12377 (2011).

  • 152.

    Marcotte, R. et al. essential gene profiles in breast, pancreatic, and ovarian cancer cells. melanoma Discov. 2, 172–189 (2012).

  • 153.

    Barretina, J. et al. The melanoma telephone Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603–607 (2012).

  • 154.

    Anderson, S. N., Towne, D. L., Burns, D. J. & Warrior, U. A excessive-throughput soft agar assay for identification of anticancer compound. J. Biomol. disclose 12, 938–945 (2007).

  • one hundred fifty five.

    Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B. & Hemann, M. T. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma development. Nature Genet. 41, 1133–1137 (2009).

  • 156.

    Zuber, J. et al. An built-in mode to dissecting oncogene addiction implicates a MYB-coordinated self-renewal application as basic for leukemia upkeep. Genes Dev. 25, 1628–1640 (2011).

  • 157.

    Possemato, R. et al. functional genomics demonstrate that the serine synthesis pathway is primary in breast cancer. Nature 476, 346–350 (2011).

  • 158.

    Murugaesu, N. et al. An in vivo useful screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor. melanoma Discov. 4, 304–317 (2014).

  • 159.

    Schramek, D. et al. Direct in vivo RNAi panoply unveils myosin IIa as a tumor suppressor of squamous cellphone carcinomas. Science 343, 309–313 (2014).

  • a hundred and sixty.

    Zender, L. et al. An oncogenomics-primarily based in vivo RNAi screen identifies tumor suppressors in liver cancer. mobile one hundred thirty five, 852–864 (2008).

  • 161.

    Kumar, M. S. et al. The GATA2 transcriptional network is requisite for RAS oncogene-pushed non-small cellphone lung melanoma. telephone 149, 642–655 (2012).

  • 162.

    Luo, T. et al. STK33 kinase inhibitor BRD-8899 has no effect on KRAS-elegant cancer phone viability. Proc. Natl Acad. Sci. united states 109, 2860–2865 (2012).

  • 163.

    Muvaffak, A. et al. Evaluating TBK1 as a therapeutic goal in cancers with activated IRF3. Mol. cancer Res. 12, 1055–1066 (2014).

  • 164.

    Zhu, Z. et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. cancer Discov. four, 452–465 (2014).

  • 165.

    Corcoran, R. B. et al. synthetic deadly interplay of mixed BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer fashions. cancer cell 23, 121–128 (2013).

  • 166.

    Ran, F. A. et al. Genome engineering the exercise of the CRISPR-Cas9 system. Nature Protoc. 8, 2281–2308 (2013).

  • 167.

    Shalem, O. et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84–87 (2014).

  • 168.

    Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells the usage of the CRISPR-Cas9 equipment. Science 343, 80–eighty four (2014).

  • 169.

    Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. realizing the Warburg impact: the metabolic requirements of mobile proliferation. Science 324, 1029–1033 (2009).

  • a hundred and seventy.

    DeBerardinis, R. J. & Thompson, C. B. mobile metabolism and sickness: what execute metabolic outliers train us? mobile 148, 1132–1144 (2012).

  • 171.

    Lunt, S. Y. & Vander Heiden, M. G. aerobic glycolysis: meeting the metabolic requirements of cellphone proliferation. Annu. Rev. mobile Dev. Biol. 27, 441–464 (2011).

  • 172.

    Stine, Z. E. & Dang, C. V. Stress consuming and tuning out: cancer cells re-wire metabolism to counter stress. Crit. Rev. Biochem. Mol. Biol. forty eight, 609–619 (2013).

  • 173.

    Levine, A. J. & Puzio-Kuter, A. M. The wield of the metabolic swap in cancers by passage of oncogenes and tumor suppressor genes. Science 330, 1340–1344 (2010).

  • 174.

    Racker, E., Resnick, R. J. & Feldman, R. Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes. Proc. Natl Acad. Sci. united states of america eighty two, 3535–3538 (1985).

  • one hundred seventy five.

    intelligent, D. R. et al. MYC regulates a transcriptional application that stimulates mitochondrial glutaminolysis and leads to glutamine dependancy. Proc. Natl Acad. Sci. country one hundred and five, 18782–18787 (2008).

  • 176.

    Son, J. et al. Glutamine helps pancreatic melanoma growth via a KRAS-regulated metabolic pathway. Nature 496, 101–a hundred and five (2013). This paper suggests that pancreatic cancers depend on glutamine, which is utilized via a KRAS-regulated pathway this is essential for preserving redox homeostasis.

  • 177.

    White, E. Exploiting the hazardous ingesting habits of RAS-driven cancers. Genes Dev. 27, 2065–2071 (2013).

  • 178.

    Yang, Z. & Klionsky, D. J. Eaten alive: a historical past of macroautophagy. Nature telephone Biol. 12, 814–822 (2010).

  • 179.

    Kimmelman, A. C. The dynamic nature of autophagy in melanoma. Genes Dev. 25, 1999–2010 (2011).

  • a hundred and eighty.

    Mah, L. Y. & Ryan, okay. M. Autophagy and cancer. bloodless Spring Harb. Perspect. Biol. 4, a008821 (2012).

  • 181.

    White, E. Deconvoluting the context-dependent function for autophagy in cancer. Nature Rev. melanoma 12, 401–410 (2012).

  • 182.

    Guo, J. Y. et al. Activated RAS requires autophagy to hold oxidative metabolism and tumorigenesis. Genes Dev. 25, 460–470 (2011).

  • 183.

    Guo, J. Y. et al. Autophagy suppresses evolution of KRAS-caused lung tumors to oncocytomas and continues lipid homeostasis. Genes Dev. 27, 1447–1461 (2013).

  • 184.

    Lock, R. et al. Autophagy facilitates glycolysis during RAS-mediated oncogenic transformation. Mol. Biol. cell 22, a hundred sixty five–178 (2011).

  • 185.

    Yang, S. et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25, 717–729 (2011).

  • 186.

    Rao, S. et al. A twin function for autophagy in a murine mannequin of lung cancer. Nature Commun. 5, 3056 (2014).

  • 187.

    Rosenfeldt, M. T. et al. p53 fame determines the position of autophagy in pancreatic tumour construction. Nature 504, 296–300 (2013).

  • 188.

    Yang, A. et al. Autophagy is vital for pancreatic tumor boom and evolution in tumors with p53 differences. cancer Discov. 4, 905–913 (2014).

  • 189.

    Amaravadi, R. ok. et al. ideas and latest recommendations for concentrated on autophagy for cancer treatment. Clin. cancer Res. 17, 654–666 (2011).

  • 190.

    Mancias, J. D. & Kimmelman, A. C. concentrated on autophagy addiction in melanoma. Oncotarget 2, 1302–1306 (2011).

  • 191.

    Prior, I. A., Lewis, P. D. & Mattos, C. A complete survey of RAS mutations in melanoma. cancer Res. seventy two, 2457–2467 (2012).

  • 192.

    Yang, Z. & Klionsky, D. J. Mammalian autophagy: core molecular rig and signaling legislation. Curr. Opin. mobile Biol. 22, 124–131 (2010).

  • 193.

    Bar-Sagi, D. & Feramisco, J. R. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts through ras proteins. Science 233, 1061–1068 (1986).

  • 194.

    Lim, J. P. & Gleeson, P. A. Macropinocytosis: an endocytic pathway for internalising gigantic gulps. Immunol. cell Biol. 89, 836–843 (2011).

  • 195.

    Commisso, C. et al. Macropinocytosis of protein is an amino acid provide route in RAS-changed cells. Nature 497, 633–637 (2013).

  • 196.

    Kamphorst, J. J. et al. Hypoxic and RAS-changed cells pilot multiply via scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl Acad. Sci. u . s . a hundred and ten, 8882–8887 (2013).

  • 197.

    Yun, J. et al. Glucose deprivation contributes to the evolution of KRAS pathway mutations in tumor cells. Science 325, 1555–1559 (2009).

  • 198.

    McCleland, M. L. et al. Lactate dehydrogenase B is required for the multiply of KRAS-elegant lung adenocarcinomas. Clin. cancer Res. 19, 773–784 (2013).

  • 199.

    Patra, ok. C. et al. Hexokinase 2 is required for tumor initiation and upkeep and its systemic deletion is therapeutic in mouse models of cancer. melanoma cellphone 24, 213–228 (2013).

  • 200.

    Gaglio, D. et al. Oncogenic KRAS decouples glucose and glutamine metabolism to assist melanoma cell increase. Mol. Syst. Biol. 7, 523 (2011).

  • 201.

    Weinberg, F. et al. Mitochondrial metabolism and ROS generation are fundamental for KRAS-mediated tumorigenicity. Proc. Natl Acad. Sci. united states of america 107, 8788–8793 (2010).

  • 202.

    Shukla, k. et al. Design, synthesis, and pharmacological assessment of bis-2-(5-phenylacetamido-1,2,four-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J. Med. Chem. 55, 10551–10563 (2012).

  • 203.

    Thornburg, J. M. et al. focused on aspartate aminotransferase in breast melanoma. Breast cancer Res. 10, R84 (2008).

  • 204.

    Nguyen, T., Nioi, P. & Pickett, C. B. The NRF2-antioxidant response element signaling pathway and its activation through oxidative stress. J. Biol. Chem. 284, 13291–13295 (2009).

  • 205.

    DeNicola, G. M. et al. Oncogene-brought about Nrf2 transcription promotes ROS detoxing and tumorigenesis. Nature 475, 106–109 (2011).

  • 206.

    To, M. D. et al. Kras regulatory points and exon 4A verify mutation specificity in lung melanoma. Nature Genet. 40, 1240–1244 (2008).

  • 207.

    Lampson, B. L. et al. infrequent codons alter KRAS oncogenesis. Curr. Biol. 23, 70–seventy five (2013).

  • 208.

    Abubaker, J. et al. Prognostic significance of ameliorations in KRAS isoforms KRAS4A/4B and KRAS mutations in colorectal carcinoma. J. Pathol. 219, 435–445 (2009).

  • 209.

    De Roock, W. et al. affiliation of KRAS p.G13D mutation with outcomes in sufferers with chemotherapy-refractory metastatic colorectal cancer handled with cetuximab. JAMA 304, 1812–1820 (2010).

  • 210.

    Tejpar, S. et al. association of KRAS G13D tumor mutations with effect in sufferers with metastatic colorectal melanoma handled with first-line chemotherapy with or with out cetuximab. J. Clin. Oncol. 30, 3570–3577 (2012).

  • 211.

    Ihle, N. T. et al. effect of KRAS oncogene substitutions on protein habits: implications for signaling and medical outcome. J. Natl cancer Inst. 104, 228–239 (2012).

  • 212.

    Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nature Genet. 29, 25–33 (2001).

  • 213.

    Bremner, R. & Balmain, A. Genetic adjustments in dermis tumor development: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. telephone 61, 407–417 (1990).

  • 214.

    Li, H. et al. boom inhibitory effect of untamed-classification KRAS2 gene on a colonic adenocarcinoma telephone line. World J. Gastroenterol. 13, 934–938 (2007).

  • 215.

    Qiu, W. et al. Disruption of p16 and activation of KRAS in pancreas raise ductal adenocarcinoma formation and metastasis in vivo. Oncotarget 2, 862–873 (2011).

  • 216.

    Lin, W. C. et al. HRAS types dimers on membrane surfaces by means of a protein–protein interface. Proc. Natl Acad. Sci. usa 111, 2996–3001 (2014).

  • 217.

    Xu, J. et al. preeminent role of oncogene dosage and absence of tumor suppressor exercise in NRAS-pushed hematopoietic transformation. cancer Discov. three, 993–1001 (2013).

  • 218.

    Grabocka, E. et al. Wild-category H- and N-RAS promote mutant KRAS-driven tumorigenesis by means of modulating the DNA damage response. cancer phone 25, 243–256 (2014).

  • 219.

    younger, A., Lou, D. & McCormick, F. Oncogenic and wild-type RAS play divergent roles in the regulation of mitogen-activated protein kinase signaling. cancer Discov. 3, 112–123 (2013).

  • 220.

    Vonderheide, R. H. & Nathanson, okay. L. Immunotherapy at enormous: the highway to customized melanoma vaccines. Nature Med. 19, 1098–1100 (2013).

  • 221.

    Bayne, L. J. et al. Tumor-derived granulocyte-macrophage colony-stimulating ingredient regulates myeloid inflammation and T phone immunity in pancreatic cancer. cancer telephone 21, 822–835 (2012).

  • 222.

    Pylayeva-Gupta, Y., Lee, k. E., Hajdu, C. H., Miller, G. & Bar-Sagi, D. Oncogenic KRAS-triggered GM-CSF production promotes the evolution of pancreatic neoplasia. melanoma mobile 21, 836–847 (2012). This peek at, along with reference 221, described crucial mechanisms of crosstalk between the immune rig and tumour construction.

  • 223.

    Pecot, C. V., Calin, G. A., Coleman, R. L., Lopez-Berestein, G. & Sood, A. ok. RNA interference in the hospital: challenges and future instructions. Nature Rev. cancer 11, 59–67 (2011).

  • 224.

    Thompson, H. J. et al. Sulfone metabolite of sulindac inhibits mammary carcinogenesis. melanoma Res. 57, 267–271 (1997).

  • 225.

    Sarthy, A. V. et al. Survivin depletion preferentially reduces the survival of activated KRAS-modified cells. Mol. cancer Ther. 6, 269–276 (2007).

  • 226.

    Morgan-Lappe, S. E. et al. Identification of RAS-related nuclear protein, targeting protein for Xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-primarily based reveal. melanoma Res. sixty seven, 4390–4398 (2007).

  • 227.

    Scholl, C. et al. ersatz deadly interplay between oncogenic KRAS dependency and STK33 suppression in human cancer cells. phone 137, 821–834 (2009).

  • 228.

    Vicent, S. et al. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human fashions. J. Clin. invest. a hundred and twenty, 3940–3952 (2010).

  • 229.

    Wang, Y. et al. captious function for transcriptional repressor SNAIL2 in transformation through oncogenic RAS in colorectal carcinoma cells. Oncogene 29, 4658–4670 (2010).

  • 230.

    Singh, A. et al. TAK1 inhibition promotes apoptosis in KRAS-based colon cancers. phone 148, 639–650 (2012).

  • 231.

    Cullis, J. et al. The RHOGEF GEF-H1 is required for oncogenic RAS signaling by means of KSR1. melanoma cell 25, 181–195 (2014).

  • Yum! brands experiences Third-Quarter EPS growth of 14%, excluding special gadgets; China earnings recovery Continues despite the fact Slower-than-anticipated pace and more advantageous international trade ... | existent questions with brain dumps

    LOUISVILLE, Ky.--(business WIRE)--Yum! manufacturers, Inc. (NYSE: YUM) these days pronounced outcomes for the third quarter ended September 5, 2015, including EPS of $1.00, aside from particular items. said EPS become $0.95.


  • global device earnings grew 6%. global restaurant margin improved three.3 percentage elements to 18.2%, and global operating profit elevated 23%.
  • total strange construction changed into 376 modern restaurants; seventy two% of this structure came about in emerging markets.
  • China Division system sales elevated eight%, driven by means of 7% unit growth and a pair of% identical-save sales increase. Restaurant margin elevated 4.7 percent aspects to 19.6%. working profit accelerated sixty four%.
  • KFC Division rig sales elevated 6%, pushed with the aid of 3% unit multiply and three% equal-shop earnings increase. working margin decreased 0.2 percent points to 21.7%. working income extended three%.
  • Pizza Hut Division system revenue accelerated 2%, driven by using 2% unit multiply and 1% identical-save earnings increase. operating margin diminished 0.7 percentage elements to 25.4%. operating profit changed into even.
  • Taco Bell Division rig earnings expanded 7%, pushed by means of three% unit multiply and four% same-store income growth. working margin decreased 0.1 percentage points to 28.0%. operating profit multiplied 6%.
  • India Division system revenue decreased 9%, as 10% unit multiply was offset by an 18% identical-store sales decline.
  • international helpful tax rate extended to 24.8% from 22.four%.
  • foreign currency translation negatively impacted operating income with the aid of $29 million.
  • FULL-year CHINA revenue AND EPS replace

    whereas it remains difficult to forecast China revenue, they are now estimating full-year identical-store earnings to exist low-single-digit bad. For the fourth quarter, this assumes mid-single-digit same-keep revenue growth for the Division, with tremendous equal-shop revenue growth at KFC and poor equal-keep income at Pizza Hut informal eating. Given a slower-than-expected recovery in China earnings, specially at Pizza Hut informal eating, in addition to more desirable strange trade headwinds, they now hope full-yr EPS multiply to exist low-single-digit nice.


    Third Quarter







    % exchange





    % trade

    EPS excluding special objects $1.00 $0.87 14% $2.50 $2.48 1% special objects gain/(Loss)1 $(0.05) $0.02 NM $(0.21) $0.02 NM EPS   $0.ninety five   $0.89   6%   $2.29   $2.50   (9)%

    1 contemplate Reconciliation of Non-GAAP Measurements to GAAP effects for further element of particular items. particular items in 2015 are basically related to a non-money can imbue associated with refranchising their Mexico company and funds related to the recent agreement with KFC U.S. franchisees, partially offset by U.S. refranchising positive aspects.


    observe: everything comparisons are versus the equal length a 12 months in the past and exclude particular gadgets until cited. device income and operating income figures on this page exclude overseas currency translation; restaurant margin and working margin figures are as stated.


    GREG CREED comments

    Greg Creed, CEO, pointed out “Third-quarter EPS grew 14%. We’re lighthearted identical-keep earnings turned superb and they finished restaurant margins of essentially 20% in their China company. despite the fact, the pace of healing in their China Division is beneath their expectations. backyard of China, their Taco Bell and KFC Divisions persevered to preserve their grotesque earnings momentum while Pizza Hut turned into rather flat. Given their lower full-year expectations in China, combined with additional strange change absorb an effect on, they now are expecting 2015 EPS multiply to exist neatly below their target of as a minimum 10%.

    Our growth fundamentals in China, including new-unit construction, remain intact. youngsters, we’re experiencing surprising headwinds, making the 2d half of the yr extra challenging than they anticipated. Their modern China Division CEO, Micky Pant, and his leadership team are taking significant movements to catch revenue, site visitors and earnings returned to ancient stages. backyard of China, KFC endured its solid growth across each rising and developed markets. Taco Bell’s equal-store revenue boom was boosted through insight-pushed innovation coupled with business-main cost. They continue to exist assured within the movements underway at Pizza Hut to turn this company around longer term.

    Our germane direct is still constructing three iconic, global brands people absorb confidence and champion. they are concentrated on the three keys to using shareholder price: new-unit building, same-shop income growth, and lofty returns on invested capital. I’m confident that this formulation will defer robust, sustainable EPS growth over the future. As proof of this, we’re lighthearted to advertise a 12% boost to their quarterly dividend, which marks the eleventh consecutive yr we’ve raised their dividend at a double-digit percent price.”



    Third Quarter



        % exchange     % change






    Ex F/X






    Ex F/X

    gadget sales growth +7 +8 (1) Even equal-keep revenue growth (%) +2 (14) NM NM (6) +1 NM NM Franchise & License prices ($MM) 34 31 +13 +14 eighty three 80 +four +6 Restaurant Margin (%) 19.6 14.9 four.7 4.7 17.7 17.9 (0.2) (0.1) working profit ($MM)       327     202     +62     +64     661     681     (3)     (1)  
  • China Division rig earnings elevated eight%, ahead of overseas strange money translation.
  • identical-shop revenue multiplied 2%, with an multiply of three% at KFC, partially offset by means of a decline of 1% at Pizza Hut casual eating.
  • bad same-save revenue within the first half of the quarter absorb been greater than offset by using sales growth within the second half of the quarter, as sales turned significantly lofty trait after they overlapped the industry enterprise incident on July 20th of remaining 12 months.
  • China Division opened 108 modern gadgets everything over the quarter.
  •   China units       Q3 2015       % Change2 Restaurants1       6,867       +7 KFC 4,889 +fivePizza Hut casual eating 1,421 +21 home carrier       284       +26

    1 complete contains East Dawning and petite Sheep instruments.

    2 Represents yr-over-year alternate.

  • Restaurant margin turned into 19.6%, an multiply of 4.7 percent aspects driven through productiveness initiatives and earnings leverage.
  • overseas strange money translation negatively impacted working income through $four million.


    Third Quarter


    12 months-to-Date

            % exchange         % trade





    Ex F/X





    Ex F/X

    eating places 14,316 13,961 +three NA 14,316 13,961 +3 NA system income increase (6) +6 (three) +7 identical-shop earnings multiply (%) +3 +3 NM NM +3 +2 NM NM Franchise & License charges ($MM) 193 205 (6) +6 579 596 (3) +7 Restaurant Margin (%) 14.0 13.4 0.6 0.7 14.9 13.1 1.eight 1.7 operating earnings ($MM) 150 169 (11) +3 471 487 (three) +8 working Margin (%)       21.7     21.9     (0.2)     (0.four)     23.2     22.2     1.0     0.6  
  • KFC Division system income multiplied 6%, with the exception of overseas strange money translation.
  •       Third Quarter (% trade)       Int'l rising Markets     Int'l Developed Markets           U.S.       system income boom (Ex F/X) +eleven%     +6%           Even     identical-store sales growth     +three%     +3%          


  • KFC Division opened 141 modern overseas eating places in 45 nations, together with a hundred and one devices in rising markets. 82% of those modern contraptions were opened through franchisees.
  • operating margin reduced 0.2 percentage points, including bigger promoting fee as a participate of their fresh agreement with KFC U.S. franchisees, partly offset by passage of an multiply of 0.6 percent points in restaurant margin.
  • overseas currency translation negatively impacted operating earnings by using $23 million, as about ninety% of division earnings are generated backyard the U.S.



    p.c of KFC

    gadget Sales2

        system revenue growth Ex F/X         Third Quarter (%)     12 months-to-Date (%) emerging Markets     Asia (e.g. Malaysia, Indonesia, Philippines) eight% +6 +fiveAfrica 7% +6 +11 Latin the united states (e.g. Mexico, Peru) 6% +eight +eight middle East / North Africa 6% +three +three Russia four% +45 +45 Thailand 3% +three +6 Continental Europe (e.g. Poland) 2% +14 +14   Developed Markets


    24% Even +2 Asia (e.g. Japan, Korea, Taiwan) 10% +10 +three Australia 10% +8 +9U.okay. 9% +1 +four Continental Europe (e.g. France, Germany) 7% +eight +eight Canada three% +1 +1 Latin the united states (e.g. Puerto Rico)     1%     (1)     +three

    1 contemplate web page under tab "investors" for a listing of the countries within every of the markets.

    2 displays plenary yr 2014.




    Third Quarter


    12 months-to-Date

            % trade         % alternate





    Ex F/X





    Ex F/X

    eating places 13,616 13,393 +2 NA 13,616 13,393 +2 NA gadget sales increase (3) +2 (2) +2 identical-keep income growth (%) +1 (1) NM NM Even (2) NM NM Franchise & License expenses ($MM) 121 124 (3) +three 367 374 (2) +2 Restaurant Margin (%) 7.eight eight.9 (1.1) (1.6) 9.8 9.0 0.eight 0.3 operating earnings ($MM) 67 68 (three) Even 208 215 (four) (1) operating Margin (%)       25.four     26.1     (0.7)     (1.0)     26.0     27.1     (1.1)     (1.2)  
  • Pizza Hut Division rig income improved 2%, except overseas currency translation.
  •       Third Quarter (% change)       Int'l rising Markets     Int'l Developed Markets           U.S.       device revenue multiply (Ex F/X) +9%     +1%           Even     equal-store income growth     +four%     Even           Even      
  • Pizza Hut Division opened a hundred and five modern strange eating places in 38 countries, including 46 devices in rising markets. ninety five% of those modern contraptions had been opened through franchisees.
  • operating margin declined 0.7 percentage elements, pushed through strategic investments in strange G&A.
  • international currency translation negatively impacted operating income through $2 million.

    % of Pizza

    Hut device Sales2

        equipment earnings boom Ex F/X         Third Quarter (%)     12 months-to-Date (%) emerging Markets     Latin the usa (e.g. Mexico, Peru) 7% +11 +eight Asia (e.g. Malaysia, Indonesia, Philippines) 5% +four +3 middle East / North Africa 5% +eight +7 Continental Europe (e.g. Poland) 1% +12 +9   Developed Markets U.S. 55% Even Even Asia (e.g. Japan, Korea, Taiwan) 9% Even (1) U.okay. 6% +6 +4 Continental Europe (e.g. France, Germany) 5% +2 +three Australia 3% (9) (6) Canada 3% +7 +fiveLatin america (e.g. Puerto Rico)     1%     (5)     Even

    1 contemplate web site beneath tab "buyers" for a list of the nations inside every of the markets.

    2 displays plenary 12 months 2014.




    Third Quarter



            % change         % change





    Ex F/X





    Ex F/X

    restaurants 6,314 6,109 +three NA 6,314 6,109 +three NA gadget sales boom +7 +7 +8 +eight same-save earnings multiply (%) +4 +3 NM NM +5 +1 NM NM Franchise & License charges ($MM) 107 ninety nine +8 +8 309 281 +10 +10 Restaurant Margin (%) 22.1 20.7 1.4 1.four 21.6 18.1 3.5 three.5Operating income ($MM) 132 124 +6 +6 387 317 +22 +22 working Margin (%)       28.0     28.1     (0.1)     (0.1)     28.1     24.9     3.2     three.2  
  • Taco Bell Division system sales extended 7%, driven by 4% equal-store earnings boom and 3% unit growth.
  • Taco Bell Division opened sixty two modern restaurants; eighty one% of those modern gadgets were opened by passage of franchisees.
  • Restaurant margin turned into 22.1%, an multiply of 1.four percent aspects, pushed by using same-store income boom.
  • working margin diminished 0.1 percent features, driven with the aid of an multiply in G&A related to incentive compensation and pension. This changed into largely offset via a tower of 1.4 percentage aspects in restaurant margin.

  • India Division device earnings decreased 9% previous to strange foreign money translation, as 10% unit multiply became offset via an 18% identical-store income decline.
  • operating loss turned into $eight million, as compared to an working lack of $3 million in prior 12 months.
  •   India devices       Q3 2015       % Change2 Restaurants1       811       +10 KFC 378 +10 Pizza Hut casual dining 175 (4) domestic service       251       +23

    1 total contains 7 Taco Bell contraptions.

    2 Represents 12 months-over-yr trade.


    particular items / participate REPURCHASE update / DIVIDEND enhance

  • For the third quarter in the U.S., they refranchised 24 gadgets, primarily regarding Taco Bell, for proceeds of $30 million. They recorded pre-tax U.S. refranchising beneficial properties of $16 million in special items. at the conclude of the third quarter, their industry ownership in the U.S. throughout their three branded divisions become 9%.
  • throughout the primary quarter of 2015, they reached an settlement with their KFC U.S. franchisees with the end to supply us manufacturer advertising and marketing manage, as well as an accelerated route to elevated menu offerings, more suitable assets and an enhanced consumer event. In reference to this agreement, they diagnosed a distinct objects can imbue of $21 million during the quarter, primarily regarding the funding of investments for brand modern back-of-residence gadget for franchisees.
  • all the passage through the quarter, they recorded a $20 million refranchising loss in particular gadgets involving the planned refranchising of positive strange markets.
  • yr-to-date through October 5, 2015, they repurchased 4.5 million shares totaling $370 million at an middling fee of $82.
  • The enterprise’s Board of administrators approved a 12% multiply within the business’s quarterly dividend. The quarterly cash dividend will enhance from $0.forty one to $0.46 per participate and will exist positive with the dividend charge to exist disbursed on November 6, 2015 to shareholders of record at the proximate of company on October sixteen, 2015. This raise raises the annual dividend charge to $1.84 per share. Over the long term, Yum! is now concentrated on a payout ratio of 45% to 50% of annual internet income, before special gadgets.
  • convention name

    Yum! brands, Inc. will host a conference title to evaluate the enterprise’s monetary performance and techniques at 9:15 a.m. japanese Time Wednesday, October 7, 2015. The number is 877/815-2029 for U.S. callers and 706/645-9271 for overseas callers.

    The muster could exist available for playback tower at 12:30 p.m. eastern Time Wednesday, October 7, through inanimate night Saturday, November 7, 2015. To access the playback, dial 855/859-2056 within the u.s. and 404/537-3406 internationally. The playback rush code is 98023873.

    The webcast and the playback will besides exist accessed by means of the internet by using touring Yum! manufacturers’ website, and determining “Q3 2015 revenue convention call” beneath “movements & presentations.” A podcast should exist purchasable inside 24 hours.

    additional information online

    Quarter conclude dates for every division, restaurant-count number details and definitions of phrases are available online at under “buyers.”

    This announcement, any related bulletins and the linked webcast can besides comprise “ahead-looking statements” inside the that means of belt 27A of the Securities Act of 1933 and belt 21E of the Securities trade Act of 1934. They intend everything ahead-searching statements to exist covered with the aid of the secure harbor provisions of the inner most Securities Litigation Reform Act of 1995. ahead-searching statements can exist recognized by using the undeniable fact that they don't relate strictly to traditional or existing facts. Their forward-looking statements are discipline to dangers and uncertainties, which can intuition genuine outcomes to vary materially from these projected. components that may intuition their actual consequences to vary materially consist of, but aren't restricted to: meals safety and food borne-ailment considerations; adjustments in economic conditions, customer preferences, tax fees and laws and the regulatory ambiance, in addition to elevated competition and different dangers in China, the residence a significant and growing component of their restaurants are located; the impact or probability of any widespread disorder or outbreaks of viruses or other illnesses; changes in economic and political situations in the other nations outdoor the U.S. the residence they function; their capacity to protect the integrity and security of in my view identifiable information of their customers and employees; their means to relaxed and retain distribution and adequate deliver to their eating places; the success of their overseas construction approach; commodity, labor and other working costs; the endured viability and success of their franchise and license operators; consumer preferences and perceptions of their manufacturers; the absorb an effect on of convivial media; pending or future litigation and prison claims or complaints; changes in or noncompliance with executive regulations; tax concerns, including disagreements with taxing authorities; huge changes in world financial situations, together with client spending, customer confidence and unemployment; and competition within the retail food business, including with respect to expense and high-quality of food items, modern product construction, promoting degrees and promotional initiatives, client service, popularity, restaurant location, and splendor and protection of residences. you should definitely consult their filings with the Securities and alternate fee (together with the tips set forth beneath the captions “risk elements” and “forward-looking Statements” in their Annual file on benign 10-k) for extra aspect about components that might strike their economic and other consequences. ahead-searching statements are according to present expectations and assumptions and presently attainable records and are neither predictions nor guarantees of future events or efficiency. you'll want to now not vicinity undue reliance on ahead-searching statements, which talk handiest as of the date hereof. They don't look to exist accomplishing to supersede any of these statements.

    Yum! manufacturers, Inc., based in Louisville, Kentucky, has over 41,000 restaurants in more than 125 international locations and territories. Yum! is ranked #228 on the Fortune 500 record with revenues of over $13 billion in 2014 and is likely one of the Aon Hewitt properly organizations for Leaders in North the usa. The enterprise’s restaurant brands - KFC, Pizza Hut and Taco Bell - are the world leaders of the bird, pizza and Mexican-fashion food categories. outdoor the U.S., the Yum! manufacturers rig opens over 5 modern restaurants per day on regular, making it a pacesetter in international retail construction.


    YUM! manufacturers, Inc.

    Condensed Consolidated summary of consequences

    (amounts in tens of millions, except per participate quantities)


      Quarter ended % alternate year so far % alternate 9/5/15     9/6/14 B/(W) 9/5/15     9/6/14 B/(W)   enterprise revenue $ 2,968 $ 2,891 three $ 7,806 $ 7,941 (2) Franchise and license prices and revenue 459   463   (1) 1,348   1,341   — complete revenues 3,427   three,354   2 9,154   9,282   (1)   enterprise restaurant fees food and paper 933 951 2 2,462 2,562 4 Payroll and employee advantages 625 642 3 1,720 1,755 2 Occupancy and different operating fees 871   869   — 2,292   2,326   1 enterprise restaurant prices 2,429 2,462 1 6,474 6,643 three   normal and administrative costs 328 323 (1) 976 946 (three) Franchise and license prices sixty five 42 (54) 146 109 (34) Closures and impairment (revenue) fees 3 6 forty eight 30 30 2 Refranchising (profit) loss 2 (20 ) NM 60 (27 ) NM other (revenue) expense (3 ) (9 ) (sixty seven) (12 ) (19 ) (38) total prices and charges, net 2,824   2,804   (1) 7,674   7,682   —   working earnings 603 550 10 1,480 1,600 (7) interest expense, internet 32   28   (eleven) 99   ninety   (9) income before profits taxes 571 522 10 1,381 1,510 (9) revenue tax provision one hundred forty five   119   (22) 358   370   3 internet income - including noncontrolling pastimes 426 403 6 1,023 1,140 (10) net earnings (loss) - noncontrolling pursuits 5   (1 ) NM 5   three   (72) net revenue - YUM! brands, Inc. $ 421   $ 404   four $ 1,018   $ 1,137   (10)  

    effective tax price

    25.3 % 22.7 % (2.6 ppts.) 25.9 % 24.5 % (1.4 ppts.)  

    basic EPS records

    EPS $ 0.97   $ 0.ninety one   6 $ 2.33   $ 2.55   (9) average shares astounding 436   443   2 437   445   2  

    Diluted EPS records

    EPS $ 0.95   $ 0.89   6 $ 2.29   $ 2.50   (9) typical shares fabulous 444   452   2 445   455   2   Dividends declared per middling share $ —   $ —   $ 0.eighty two   $ 0.seventy four    

    See accompanying notes.


    Percentages may additionally not recompute due to rounding.


    YUM! manufacturers, Inc.

    CHINA DIVISION working outcomes

    (amounts in millions)


      Quarter ended % change year to this point % change 9/5/15     9/6/14 B/(W) 9/5/15     9/6/14 B/(W)   company sales $ 1,935 $ 1,809 7 $ 4,778 $ four,848 (1) Franchise and license fees and profits 34   31   13 eighty three   eighty   4 complete revenues 1,969   1,840   7 four,861   four,928   (1)   enterprise restaurant fees food and paper 611 598 (2) 1,518 1,547 2 Payroll and worker advantages 356 366 3 933 944 1 Occupancy and other working expenses 589   576   (2) 1,481   1,488   — business restaurant expenses 1,556 1,540 (1) 3,932 three,979 1 popular and administrative costs ninety ninety five 5 258 259 — Franchise and license costs 6 5 (21) 15 eleven (34) Closures and impairment (income) prices 3 4 23 22 23 6 other (income) expense (13 ) (6 ) NM (27 ) (25 ) 5 1,642   1,638   — four,200   four,247   1 operating income $ 327   $ 202   62 $ 661   $ 681   (three)   business sales one hundred.0 % a hundred.0 % one hundred.0 % one hundred.0 % food and paper 31.6 33.1 1.5 ppts. 31.eight 31.9 0.1 ppts. Payroll and worker merits 18.four 20.2 1.eight ppts. 19.5 19.5 — Occupancy and other working expenses 30.four   31.8   1.4 ppts. 31.0   30.7   (0.three ppts.) Restaurant margin 19.6 % 14.9 % 4.7 ppts. 17.7 % 17.9 % (0.2 ppts.)   working margin 16.6 % eleven.0 % 5.6 ppts. 13.6 % 13.eight % (0.2 ppts.)  

    See accompanying notes.


    Percentages might besides not recompute because of rounding.


    YUM! brands, Inc.

    KFC DIVISION operating outcomes

    (quantities in tens of millions)


      Quarter ended % change yr thus far % change 9/5/15     9/6/14 B/(W) 9/5/15     9/6/14 B/(W)   business earnings $ 501 $ 566 (12) $ 1,451 $ 1,593 (9) Franchise and license prices and earnings 193   205   (6) 579   596   (3) total revenues 694   771   (10) 2,030   2,189   (7)   enterprise restaurant costs food and paper 171 197 13 495 555 eleven Payroll and employee merits a hundred and twenty 135 11 342 384 eleven Occupancy and other operating expenses a hundred and forty   158   12 398   445   eleven business restaurant fees 431 490 12 1,235 1,384 eleven everyday and administrative charges 92 ninety one (1) 264 261 (1) Franchise and license charges 21 20 (6) 59 fifty four (9) Closures and impairment (earnings) charges — 1 NM 2 2 four different (salary) fee —   —  


    (1 ) 1   NM 544   602   10 1,559   1,702   eight operating profit $ one hundred fifty   $ 169   (11) $ 471   $ 487   (three)   business income a hundred.0 % 100.0 % a hundred.0 % a hundred.0 % meals and paper 34.1 34.eight 0.7 ppts. 34.1 34.9 0.eight ppts. Payroll and employee benefits 23.9 23.eight (0.1 ppts.) 23.6 24.1 0.5 ppts. Occupancy and different operating expenses 28.0   28.0   — 27.four   27.9   0.5 ppts. Restaurant margin 14.0 % 13.four % 0.6 ppts. 14.9 % 13.1 % 1.8 ppts.   working margin 21.7 % 21.9 % (0.2 ppts.) 23.2 % 22.2 % 1.0 ppts.  

    See accompanying notes.


    Percentages might besides now not recompute as a result of rounding.


    YUM! brands, Inc.

    PIZZA HUT DIVISION working results

    (quantities in millions)


      Quarter ended % change year to this point % change 9/5/15     9/6/14 B/(W) 9/5/15     9/6/14 B/(W)   company earnings $ 141 $ 140 1 $ 430 $ 422 2 Franchise and license prices and income 121   124   (three) 367   374   (2) total revenues 262   264   (1) 797   796   —   company restaurant prices food and paper 40 forty one three a hundred and twenty 126 fivePayroll and employee benefits 44 forty two (5) 133 129 (3) Occupancy and different working prices forty six   forty four   (5) a hundred thirty five   129   (5) enterprise restaurant fees one hundred thirty 127 (2) 388 384 (1) generic and administrative charges fifty eight 58 (3) 176 one hundred sixty five (eight) Franchise and license expenses 8 11 27 25 29 14 Closures and impairment (income) expenses (1 ) — NM 2 2 4 other (profits) expense —   —   NM (2 ) 1   NM 195   196   — 589   581   (2) operating income $ 67   $ sixty eight   (three) $ 208   $ 215   (four)   business sales 100.0 % one hundred.0 % 100.0 % 100.0 % meals and paper 28.0 29.1 1.1 ppts. 27.8 29.eight 2.0 ppts. Payroll and worker advantages 31.5 30.5 (1.0 ppts.) 31.0 30.6 (0.four ppts.) Occupancy and different operating fees 32.7   31.5   (1.2 ppts.) 31.four   30.6   (0.8 ppts.) Restaurant margin 7.8 % 8.9 % (1.1 ppts.) 9.eight % 9.0 % 0.eight ppts.   operating margin 25.four % 26.1 % (0.7 ppts.) 26.0 % 27.1 % (1.1 ppts.)  

    See accompanying notes.


    Percentages might besides no longer recompute as a result of rounding.


    YUM! manufacturers, Inc.

    TACO BELL DIVISION operating consequences

    (amounts in millions)


      Quarter ended % trade year to this point % trade 9/5/15     9/6/14 B/(W) 9/5/15     9/6/14 B/(W)   business earnings $ 366 $ 344 6 $ 1,071 $ 992 8 Franchise and license expenses and profits 107   99   eight 309   281   10 total revenues 473   443   7 1,380   1,273   8   company restaurant costs food and paper 100 101 1 297 297 — Payroll and employee advantages one hundred 95 (6) 299 287 (5) Occupancy and different operating costs 84   seventy eight   (9) 243   229   (6) company restaurant charges 284 274 (four) 839 813 (three) everyday and administrative expenses 50 forty (20) one hundred forty 128 (8) Franchise and license expenses 6 four (30) 12 13 9Closures and impairment (income) costs 1 1 NM 3 2 (76) different (profits) fee —   —   NM (1 ) —   NM 341   319   (7) 993   956   (four) operating earnings $ 132   $ 124   6 $ 387   $ 317   22   company revenue one hundred.0 % one hundred.0 % a hundred.0 % a hundred.0 % food and paper 27.three 29.2 1.9 ppts. 27.7 29.9 2.2 ppts. Payroll and employee benefits 27.5 27.6 0.1 ppts. 28.0 28.9 0.9 ppts. Occupancy and other operating expenses 23.1   22.5   (0.6 ppts.) 22.7   23.1   0.four ppts. Restaurant margin 22.1 % 20.7 % 1.4 ppts. 21.6 % 18.1 % three.5 ppts.   working margin 28.0 % 28.1 % (0.1 ppts.) 28.1 % 24.9 % 3.2 ppts.  

    See accompanying notes.


    Percentages may besides now not recompute as a result of rounding.


    YUM! brands, Inc.

    Condensed Consolidated equipoise Sheets

    (quantities in tens of millions)

      (unaudited) 9/5/15 12/27/14 belongings current property money and money equivalents $ 861 $ 578 accounts and notes receivable, much less allowance: $20 in 2015 and $12 in 2014 355 325 Inventories 230 301 pay as you depart prices and different latest belongings 248 254 Deferred earnings taxes 113 ninety three promoting cooperative property, restricted 112   ninety five   total present belongings 1,919 1,646  

    Property, plant and gadget, web of collected depreciation and amortization of $three,697 in 2015 and $three,584 in 2014

    4,263 4,498 Goodwill 674 700 Intangible assets, web 287 318 Investments in unconsolidated affiliates fifty three 52 different property 561 560 Deferred salary taxes 563   571   total assets $ 8,320   $ 8,345     LIABILITIES AND SHAREHOLDERS' fairness existing Liabilities bills payable and different present liabilities $ 1,811 $ 1,972 income taxes payable 153 77 short-term borrowings 566 267 advertising cooperative liabilities 112   95   total latest Liabilities 2,642 2,411   lengthy-term debt 2,651 3,077 other liabilities and deferred credit 1,a hundred and twenty   1,244   complete Liabilities 6,413   6,732     Redeemable noncontrolling pastime 8   9     Shareholders' equity common stock, no par price, 750 shares authorized; 431 shares and 434 shares issued in 2015 and 2014, respectively eight — Retained profits 2,079 1,737 collected different finished profits (loss) (248 ) (one hundred ninety ) total Shareholders' equity - YUM! brands, Inc. 1,839 1,547 Noncontrolling pursuits 60   fifty seven   total Shareholders' fairness 1,899   1,604   complete Liabilities, Redeemable Noncontrolling activity and Shareholders' equity $ 8,320   $ 8,345    

    See accompanying notes.


    YUM! brands, Inc.

    Condensed Consolidated Statements of cash Flows

    (quantities in tens of millions)


      yr to this point ended 9/5/15     9/6/14 money Flows - operating activities web revenue - including noncontrolling interests $ 1,023 $ 1,one hundred forty Depreciation and amortization 505 501 Closures and impairment (earnings) expenses 30 30 Refranchising (gain) loss 60 (27 ) Contributions to described profit pension plans (83 ) (17 ) Deferred income taxes (forty two ) (ninety four ) equity salary from investments in unconsolidated affiliates (31 ) (31 ) Distributions of salary got from unconsolidated associates 9 12 extra tax profit from share-based compensation (forty six ) (29 ) Share-primarily based compensation fee 40 36 changes in debts and notes receivable (15 ) (25 ) alterations in inventories sixty two 24 alterations in prepaid prices and different present property (27 ) (3 ) alterations in bills payable and other existing liabilities


    fifty nine alterations in revenue taxes payable 111 (24 ) different, net 24   60   net cash offered by passage of working actions


      1,612     cash Flows - Investing activities Capital spending (642 ) (655 ) changes in short-term investments, web (2 ) (315 ) Proceeds from refranchising of restaurants 72 sixty six different, net 50   (sixteen ) net money used in Investing activities (522 ) (920 )   money Flows - Financing activities Repayments of long-time age debt (10 ) (7 ) brief-time age borrowings by using fashioned maturity greater than three months - proceeds — 2 greater than three months - payments — — Three months or less, net — — Revolving credit facilities, three months or less, web (116 ) 397 Repurchase shares of established stock (370 ) (510 ) extra tax improvement from share-based mostly compensation 46 29 employee inventory alternative proceeds 12 21 Dividends paid on ordinary stock (532 ) (490 ) other, net


    ) (28 ) internet cash utilized in Financing actions


    ) (586 ) effect of alternate expense on cash and cash Equivalents 7   6   web raise in cash and money Equivalents 283 112 cash and cash Equivalents - starting of duration 578   573   cash and cash Equivalents - conclusion of length $ 861   $ 685    

    See accompanying notes.


    Reconciliation of Non-GAAP Measurements to GAAP outcomes(quantities in millions, except per participate quantities)(unaudited)

      apart from the consequences supplied according to U.S. frequently authorized Accounting concepts ("GAAP") throughout this doc, the enterprise has supplied non-GAAP measurements which current working results in 2015 and 2014 on a foundation before particular objects. protected in particular objects are helpful points/(losses) associated with the refranchising of equity markets backyard the U.S., fees associated with the KFC U.S. Acceleration settlement and U.S. refranchising positive factors. These amounts are described in (c), (d) and (e) in the accompanying notes.   The industry makes exercise of revenue earlier than particular items as a key efficiency measure of results of operations for the direct of evaluating performance internally and special gadgets aren't included in any of their segment outcomes. This non-GAAP dimension isn't intended to exchange the presentation of their fiscal effects in line with GAAP. quite, the company believes that the presentation of income before particular gadgets offers additional information to buyers to facilitate the comparison of previous and latest operations, excluding items in the quarters and years up to now ended September 5, 2015 and September 6, 2014 that the enterprise doesn't agree with are indicative of their ongoing operations due to their measurement and/or nature.         Quarter ended year so far 9/5/15     9/6/14 9/5/15     9/6/14 aspect of particular gadgets good points (losses) linked to the refranchising of equity markets outdoor the U.S.(c) $ (20 ) $ 7 $ (ninety three ) $ 7 costs associated with KFC U.S. Acceleration contract(d) (21 ) — (31 ) — U.S. Refranchising benefit(e) sixteen 8 24 eleven other particular items income (fee) (1 ) —   1   —   total special items income (rate) (26 ) 15 (ninety nine ) 18 Tax improvement (cost) on special gadgets 4   (5 ) 5   (6 ) particular gadgets profits (expense), internet of tax $ (22 ) $ 10   $ (94 ) $ 12   commonplace diluted shares dazzling 444   452   445   455   special items diluted EPS $ (0.05 ) $ 0.02   $ (0.21 ) $ 0.02     Reconciliation of working income earlier than particular objects to reported operating income working income before particular objects $ 629 $ 535 $ 1,579 $ 1,582 particular objects profits (rate) (26 ) 15   (99 ) 18   stated working profit $ 603   $ 550   $ 1,480   $ 1,600     Reconciliation of EPS earlier than particular gadgets to said EPS Diluted EPS earlier than particular gadgets $ 1.00 $ 0.87 $ 2.50 $ 2.48 special items EPS (0.05 ) 0.02   (0.21 ) 0.02   pronounced EPS $ 0.95   $ 0.89   $ 2.29   $ 2.50     Reconciliation of advantageous Tax fee before particular gadgets to mentioned efficacious Tax expense advantageous Tax charge earlier than special objects 24.eight % 22.four % 24.6 % 24.4 % affect on Tax cost as a result of particular gadgets 0.5 % 0.3 % 1.three % 0.1 % stated advantageous Tax cost 25.three % 22.7 % 25.9 % 24.5 %                              

    YUM! brands, Inc.

    phase outcomes

    (quantities in hundreds of thousands)


      Quarter Ended 9/5/15 China KFC Pizza Hut Taco Bell India


    Consolidated complete revenues $ 1,969   $ 694   $ 262   $ 473   $ 29   $ —   $ three,427     business restaurant prices 1,556 431 130 284 28 — 2,429 regularly occurring and administrative charges 90 92 58 50 6 32 328 Franchise and license charges 6 21 eight 6 three 21 sixty five Closures and impairment (revenue) charges three — (1 ) 1 — — three Refranchising (gain) loss — — — — — 2 2 other (salary) cost (13 ) —   —   —   —   10   (3 ) 1,642   544   195   341   37   65   2,824   operating income (loss) $ 327   $ a hundred and fifty   $ sixty seven   $ 132   $ (eight ) $ (65 ) $ 603     Quarter Ended 9/6/14 China KFC Pizza Hut Taco Bell India


    Consolidated complete revenues $ 1,840   $ 771   $ 264   $ 443   $ 36   $ —   $ 3,354     enterprise restaurant fees 1,540 490 127 274 31 — 2,462 common and administrative charges ninety five ninety one fifty eight forty 6 33 323 Franchise and license prices 5 20 eleven four 2 — 42 Closures and impairment (income) expenses four 1 — 1 — — 6 Refranchising (gain) loss — — — — — (20 ) (20 ) other (revenue) price (6 ) —   —   —   —   (three ) (9 ) 1,638   602   196   319   39   10   2,804   working profit (loss) $ 202   $ 169   $ sixty eight   $ 124   $ (3 ) $ (10 ) $ 550    

    The above tables reconcile segment assistance, which is in response to management accountability, with their Condensed Consolidated summary of results. company and unallocated fees incorporate gadgets that are not allocated to segments for performance reporting applications.


    The corporate and Unallocated column in the above tables comprises, amongst different amounts, everything quantities that they now absorb deemed particular items. contemplate Reconciliation of Non-GAAP Measurements to GAAP effects.


    YUM! brands, Inc.

    segment outcomes

    (amounts in tens of millions)


      12 months to date 9/5/15 China KFC Pizza Hut Taco Bell India


    Consolidated total revenues $ four,861   $ 2,030   $ 797   $ 1,380   $ 86   $ —   $ 9,154     business restaurant costs 3,932 1,235 388 839 eighty — 6,474 established and administrative prices 258 264 176 140 16 122 976 Franchise and license expenses 15 59 25 12 4 31 146 Closures and impairment (profits) fees 22 2 2 three 1 — 30 Refranchising (gain) loss — — — — — 60 60 other (revenue) fee (27 ) (1 ) (2 ) (1 ) —   19   (12 ) four,200   1,559   589   993   one zero one   232   7,674   operating profit (loss) $ 661   $ 471   $ 208   $ 387   $ (15 ) $ (232 ) $ 1,480     12 months to date 9/6/14 China KFC Pizza Hut Taco Bell India


    Consolidated total revenues $ four,928   $ 2,189   $ 796   $ 1,273   $ 96   $ —   $ 9,282     enterprise restaurant fees three,979 1,384 384 813 83 — 6,643 universal and administrative costs 259 261 one hundred sixty five 128 17 116 946 Franchise and license fees eleven 54 29 13 2 — 109 Closures and impairment (earnings) fees 23 2 2 2 1 — 30 Refranchising (gain) loss — — — — — (27 ) (27 ) different (profits) price (25 ) 1   1   —   —   4   (19 ) four,247   1,702   581   956   103   93   7,682   operating profit (loss) $ 681   $ 487   $ 215   $ 317   $ (7 ) $ (93 ) $ 1,600    

    The above tables reconcile segment suggestions, which is in line with administration accountability, with their Condensed Consolidated abstract of outcomes. corporate and unallocated charges accommodate gadgets that are not allotted to segments for performance reporting functions.


    The company and Unallocated column in the above tables comprises, among other amounts, everything quantities that they absorb deemed special items. contemplate Reconciliation of Non-GAAP Measurements to GAAP consequences.


    Notes to the Condensed Consolidated abstract of effects, Condensed Consolidated stability Sheetsand Condensed Consolidated Statements of cash Flows(amounts in thousands and thousands)(unaudited)



    quantities introduced as of and for the quarter and 12 months so far ended September 5, 2015 are preliminary.



    other (salary) rate for the China Division primarily contains equity (profits) loss from investments in unconsolidated associates.



    In 2010 they refranchised their then final company-operated eating places in Mexico. To the extent they owned it, they didn't promote the existent estate involving unavoidable of these eating places, in its residence leasing it to the franchisee. throughout the quarter ended June 13, 2015 they initiated plans to promote this precise property and determined it turned into held for sale according to GAAP. On September 28, 2015, subsequent to their quarter conclusion, they sold the precise property for about $fifty eight million. whereas these proceeds surpassed the publication value of the True property, the sale represents a substantial liquidation of their Mexican operations beneath U.S. GAAP. hence, they absorb been required to encompass accumulated translation losses linked to their Mexican industry inside their carrying cost when performing impairment evaluations in the quarters subsequent to making a selection on that the restaurants had been held on the market. As such, they recorded charges of $12 million and $80 million in the quarter and year so far ended September 5, 2015, respectively, representing the extra of the sum of the reserve charge of the existent property and other connected assets and their accumulated translation losses over the then anticipated sales expense. per the classification of the established market refranchising transaction, these fees had been classified as Refranchising Loss within special gadgets. They don't hope to listing further huge prices on account of the consummation of the sale.

      moreover, during the quarter and 12 months so far ended September 5, 2015 they recognized special objects prices of $eight million and $13 million, respectively, associated with the selection to present to refranchise their Pizza Hut Korea eating places. The remaining carrying value of these restaurants isn't giant. whereas further charges might besides betide as the refranchising plans shuffle ahead, such prices don't look to exist anticipated to exist cloth at this time.  


    throughout the primary quarter of 2015, they reached an settlement with their KFC U.S. franchisees that gave us manufacturer advertising control as well as an accelerated course to greater belongings and consumer journey. In connection with this constrict they diagnosed special detail expenses for the quarter and 12 months to this point ended September 5, 2015 of $21 million and $31 million, respectively, essentially related to the funding of investments for brand modern returned-of-condominium device for franchisees. They continue to hope a complete particular detail imbue of approximately $eighty million in 2015 for these and different investments they agreed to fund.



    right through the quarters ended September 5, 2015 and September 6, 2014, they recorded particular merchandise positive factors of $16 million and $8 million, respectively, related to refranchising within the U.S. privilege through the years to date ended September 5, 2015 and September 6, 2014, they recorded special detail beneficial properties of $24 million and $11 million, respectively, involving refranchising in the U.S. Refranchising positive factors and losses in the U.S. absorb been mirrored as special gadgets due to the scope of their U.S. refranchising application in recent years and the volatility in associated beneficial properties and losses.

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